RPS6KA1

HU-1 redirects here. For the helicopter, see UH-1 Iroquois.

Ribosomal protein S6 kinase, 90kDa, polypeptide 1
Rendering based on PDB 2WNT.
Available structures PDB 2WNT, 2Z7Q, 2Z7R, 2Z7S
Identifiers
Symbols	RPS6KA1; HU-1; MAPKAPK1A; RSK; RSK1
External IDs	OMIM: 601684 MGI: 104558 HomoloGene: 55703 GeneCards: RPS6KA1 Gene
EC number	2.7.11.1
Gene Ontology Molecular function • nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • protein binding • ATP binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol Biological process • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • response to stress • cell cycle • signal transduction • intracellular protein kinase cascade • synaptic transmission • axon guidance • Toll signaling pathway • positive regulation of cell growth • toll-like receptor 1 signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of translation in response to stress • regulation of DNA-dependent transcription in response to stress • innate immune response • positive regulation of cell differentiation • positive regulation of transcription from RNA polymerase II promoter • nerve growth factor receptor signaling pathway • stress-activated MAPK cascade • positive regulation of hepatic stellate cell activation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6195	20111
Ensembl	ENSG00000117676	ENSMUSG00000003644
UniProt	Q15418	P18653
RefSeq (mRNA)	NM_001006665.1	NM_009097.4
RefSeq (protein)	NP_001006666.1	NP_033123.2
Location (UCSC)	Chr 1: 26.86 – 26.9 Mb	Chr 4: 133.4 – 133.44 Mb
PubMed search	[1]	[2]

Ribosomal protein S6 kinase alpha-1 is an enzyme that in humans is encoded by the RPS6KA1 gene.

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Interactions

RPS6KA1 has been shown to interact with YWHAB, MAPK1, IκBα, TOB1 and TSC2.

See also

• Ribosomal s6 kinase

Further reading

• Chen RH, Sarnecki C, Blenis J (1992). "Nuclear localization and regulation of erk- and rsk-encoded protein kinases.". Mol. Cell. Biol. 12 (3): 915–27. PMC 369523. PMID 1545823. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=369523. 
• Tratner I, Ofir R, Verma IM (1992). "Alteration of a cyclic AMP-dependent protein kinase phosphorylation site in the c-Fos protein augments its transforming potential.". Mol. Cell. Biol. 12 (3): 998–1006. PMC 369532. PMID 1545828. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=369532. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Chen RH, Abate C, Blenis J (1994). "Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 10952–6. doi:10.1073/pnas.90.23.10952. PMC 47899. PMID 8248197. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=47899. 
• Rivera VM, Miranti CK, Misra RP, et al. (1993). "A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity". Mol. Cell. Biol. 13 (10): 6260–73. PMC 364685. PMID 8413226. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=364685. 
• Chen ZJ, Parent L, Maniatis T (1996). "Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity". Cell 84 (6): 853–62. doi:10.1016/S0092-8674(00)81064-8. PMID 8601309. 
• Barge RM, de Koning JP, Pouwels K, et al. (1996). "Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route". Blood 87 (6): 2148–53. PMID 8630373. 
• Wong EV, Schaefer AW, Landreth G, Lemmon V (1996). "Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1". J. Biol. Chem. 271 (30): 18217–23. doi:10.1074/jbc.271.30.18217. PMID 8663493. 
• Xing J, Ginty DD, Greenberg ME (1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science 273 (5277): 959–63. doi:10.1126/science.273.5277.959. PMID 8688081. 
• Nakajima T, Fukamizu A, Takahashi J, et al. (1996). "The signal-dependent coactivator CBP is a nuclear target for pp90RSK". Cell 86 (3): 465–74. doi:10.1016/S0092-8674(00)80119-1. PMID 8756728. 
• Zhao Y, Bjorbaek C, Moller DE (1997). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases". J. Biol. Chem. 271 (47): 29773–9. doi:10.1074/jbc.271.47.29773. PMID 8939914. 
• Zaheer A, Lim R (1997). "Protein kinase A (PKA)- and protein kinase C-phosphorylated glia maturation factor promotes the catalytic activity of PKA". J. Biol. Chem. 272 (8): 5183–6. doi:10.1074/jbc.272.8.5183. PMID 9030586. 
• Schouten GJ, Vertegaal AC, Whiteside ST, et al. (1997). "IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase". EMBO J. 16 (11): 3133–44. doi:10.1093/emboj/16.11.3133. PMC 1169932. PMID 9214631. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169932. 
• Li HL, Forman MS, Kurosaki T, Puré E (1997). "Syk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cells". J. Biol. Chem. 272 (29): 18200–8. doi:10.1074/jbc.272.29.18200. PMID 9218456. 
• Chang YW, Traugh JA (1997). "Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation". J. Biol. Chem. 272 (45): 28252–7. doi:10.1074/jbc.272.45.28252. PMID 9353277. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• del Peso L, González-García M, Page C, et al. (1997). "Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt". Science 278 (5338): 687–9. doi:10.1126/science.278.5338.687. PMID 9381178. 
• Dalby KN, Morrice N, Caudwell FB, et al. (1998). "Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK". J. Biol. Chem. 273 (3): 1496–505. doi:10.1074/jbc.273.3.1496. PMID 9430688. 
• Joel PB, Smith J, Sturgill TW, et al. (1998). "pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167". Mol. Cell. Biol. 18 (4): 1978–84. PMC 121427. PMID 9528769. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=121427.