Neuroblastoma RAS viral oncogene homolog

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Neuroblastoma RAS viral (v-ras) oncogene homolog
Protein NRAS PDB 121p.png
PDB rendering based on 121p.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NRAS ; ALPS4; CMNS; N-ras; NCMS; NRAS1; NS6
External IDs OMIM164790 MGI97376 HomoloGene55661 GeneCards: NRAS Gene
Orthologs
Species Human Mouse
Entrez 4893 18176
Ensembl ENSG00000213281 ENSMUSG00000027852
UniProt P01111 P08556
RefSeq (mRNA) NM_002524 NM_010937
RefSeq (protein) NP_002515 NP_035067
Location (UCSC) Chr 1:
115.25 – 115.26 Mb
Chr 3:
103.06 – 103.07 Mb
PubMed search [1] [2]

NRAS is an enzyme that in humans is encoded by the NRAS gene. It was discovered by a small team of researchers led by Robin Weiss at the Institute of Cancer Research in London.[1][2] It was the third RAS gene to be discovered, and was named NRAS, for its initial identification in human neuroblastoma cells.

Function[edit]

The N-ras oncogene is a member of the Ras gene family. It is mapped on chromosome 1, and it is activated in HL60, a promyelocytic leukemia line. The order of nearby genes is as follows: cen—CD2—NGFB—NRAS—tel. The mammalian ras gene family consists of the harvey and kirsten ras genes (HRAS and KRAS), an inactive pseudogene of each (c-Hras2 and c-Kras1) and the N-ras gene. They differ significantly only in the C-terminal 40 amino acids. These ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins involved in the normal control of cell growth. Mutations which change amino acid residues 12, 13 or 61 activate the potential of N-ras to transform cultured cells and are implicated in a variety of human tumors. The N-ras gene specifies two main transcripts of 2Kb and 4.3Kb. The difference between the two transcripts is a simple extension through the termination site of the 2Kb transcript. The N-ras gene consists of seven exons (-I, I, II, III, IV, V, VI). The smaller 2Kb transcript contains the VIa exon, and the larger 4.3Kb transcript contains the VIb exon which is just a longer form of the VIa exon. Both transcripts encode identical proteins as they differ only the 3' untranslated region. The sequence of the shorter 2Kb transcript is presented here. The 4.3 Kb transcript sequence is not available.[3]

References[edit]

  1. ^ Marshall CJ, Hall A, Weiss RA (September 1982). "A transforming gene present in human sarcoma cell lines". Nature 299 (5879): 171–3. doi:10.1038/299171a0. PMID 6287287. 
  2. ^ Shimizu K, Goldfarb M, Perucho M, Wigler M (January 1983). "Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line". PNAS 80 (2): 383–7. doi:10.1073/pnas.80.2.383. PMID 6300838. 
  3. ^ "Entrez Gene: NRAS neuroblastoma RAS viral (v-ras) oncogene homolog". 

Further reading[edit]

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