3,4-Dichloromethylphenidate: Difference between revisions
Appearance
Content deleted Content added
m Stub sorting and placement of stub template(s): nervous-system-drug-stub. See approval. Report errors and suggestions at User talk:PotatoBot. |
Updating {{drugbox}} (no changed fields - added verified revid - updated 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'DrugBank_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report [[Wikipedia talk:WikiProject |
||
Line 1: | Line 1: | ||
{{Drugbox |
{{Drugbox |
||
| verifiedrevid = |
| verifiedrevid = 443273932 |
||
| IUPAC_name = methyl (2''R'')-2-(3,4-dichlorophenyl)-2-[(2''R'')-piperidin-2-yl]acetate |
| IUPAC_name = methyl (2''R'')-2-(3,4-dichlorophenyl)-2-[(2''R'')-piperidin-2-yl]acetate |
||
| image = Dichloromethylphenidate.png |
| image = Dichloromethylphenidate.png |
Revision as of 18:51, 10 September 2011
![]() | |
Clinical data | |
---|---|
Routes of administration | Oral |
ATC code |
|
Legal status | |
Legal status |
|
Identifiers | |
| |
PubChem CID | |
ChemSpider | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C14H17Cl2NO2 |
Molar mass | 302.196 g/mol g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
threo-3,4-Dichloromethylphenidate (3,4-CTMP) is a stimulant drug related to methylphenidate. It is around 7x more potent than methylphenidate in animal studies, but has weaker reinforcing effects due to its slower onset of action.[1][2][3][4][5] However, H. M. Deutsch's discrimination ratio implies it to be more addictive than even cocaine.[6]
See also
References
- ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 8632426, please use {{cite journal}} with
|pmid=8632426
instead. - ^ Wayment, HK; Deutsch, H; Schweri, MM; Schenk, JO (1999). "Effects of methylphenidate analogues on phenethylamine substrates for the striatal dopamine transporter: potential as amphetamine antagonists?". Journal of neurochemistry. 72 (3): 1266–74. doi:10.1046/j.1471-4159.1999.0721266.x. PMID 10037500.
- ^ Schweri, MM; Deutsch, HM; Massey, AT; Holtzman, SG (2002). "Biochemical and behavioral characterization of novel methylphenidate analogs". The Journal of pharmacology and experimental therapeutics. 301 (2): 527–35. doi:10.1124/jpet.301.2.527. PMID 11961053.
- ^ Davies, HM; Hopper, DW; Hansen, T; Liu, Q; Childers, SR (2004). "Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites". Bioorganic & medicinal chemistry letters. 14 (7): 1799–802. doi:10.1016/j.bmcl.2003.12.097. PMID 15026075.
- ^ Kim, DI; Deutsch, HM; Ye, X; Schweri, MM (2007). "Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate". Journal of medicinal chemistry. 50 (11): 2718–31. doi:10.1021/jm061354p. PMID 17489581.
- ^ Schweri MM, Deutsch HM, Massey AT, Holtzman SG. Biochemical and behavioral characterization of novel methylphenidate analogs. J Pharmacol Exp Ther. 2002 May;301(2):527-35. DOI|10.1124/jpet.301.2.527 PMID 11961053