Eugeroic

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Eugeroic
Drug class
Modafinil.svg
The chemical structure of modafinil, the prototypical drug of this class.
Class identifiers
Synonyms wakefulness-promoting agent
wakefulness-promoting drug
Use Promote wakefulness and alertness
ATC code N06B
In Wikidata

Eugeroics (originally, "eugrégorique" or "eugregoric"),[1] also known as wakefulness-promoting agents and wakefulness-promoting drugs, are a class of drugs that promote wakefulness and alertness.[2][3] They are used medically for the treatment of certain sleeping disorders, such as excessive daytime sleepiness and narcolepsy.[2][3] They generally have a very low addictive potential.[2][3]

The prototypical eugeroic is modafinil; other drugs in the class include adrafinil and armodafinil. Modafinil and armodafinil have been found to act as selective, weak, atypical dopamine reuptake inhibitors.[2][3] Adrafinil is a prodrug of modafinil and therefore has the same mechanism of action as modafinil.

Examples[edit]

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Never marketed[edit]

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References[edit]

  1. ^ Milgram, Norton W.; Callahan, Heather; Siwak, Christina (2006). "Adrafinil: A Novel Vigilance Promoting Agent". CNS Drug Reviews. 5 (3): 193–212. doi:10.1111/j.1527-3458.1999.tb00100.x. ISSN 1080-563X.
  2. ^ a b c d "Provigil: Prescribing information" (PDF). United States Food and Drug Administration. Cephalon, Inc. January 2015. Retrieved 16 August 2015.
  3. ^ a b c d "Nuvigil: Prescribing information" (PDF). United States Food and Drug Administration. Cephalon, Inc. April 2015. Retrieved 16 August 2015.