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Legal status
Legal status
  • 1-(4-chlorophenyl)-2-(methylamino)-1-propanone
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.257.446 Edit this at Wikidata
Chemical and physical data
Molar mass197.66 g·mol−1
3D model (JSmol)
Melting point198 °C (388 °F)
  • ClC1=CC=C(C(C(C)NC)=O)C=C1
  • InChI=1S/C10H12ClNO/c1-7(12-2)10(13)8-3-5-9(11)6-4-8/h3-7,12H,1-2H3

4-Chloromethcathinone (also known as 4-CMC and Clephedrone) is a stimulant drug of the cathinone class that has been sold online as a designer drug.[1][2][3]


Clephedrone is an Anlage I controlled drug in Germany.

Sweden's public health agency suggested classifying 4-Chloromethcathinone (klefedron) as illegal narcotic on June 1, 2015.[4]

As of October 2015 4-CMC is a controlled substance in China.[5]

4-CMC is considered a Schedule 1 substance in Virginia.[6]

In December 2019, the UNODC announced scheduling recommendations placing 4-CMC into Schedule II.[7]

See also[edit]


  1. ^ "4-Chloromethcathinone". Cayman Chemical. Retrieved 5 September 2015.
  2. ^ Taschwer M, Weiß JA, Kunert O, Schmid MG (November 2014). "Analysis and characterization of the novel psychoactive drug 4-chloromethcathinone (clephedrone)". Forensic Science International. 244: e56-9. doi:10.1016/j.forsciint.2014.09.007. PMID 25280452.
  3. ^ Klavž J, Gorenjak M, Marinšek M (August 2016). "Suicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC". Forensic Science International. 265: 121–4. doi:10.1016/j.forsciint.2016.01.018. PMID 26890319.
  4. ^ "23 nya ämnen kan klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 1 June 2015. Retrieved 5 September 2015.
  5. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
  6. ^ "18VAC110-20-322. Placement of Chemicals in Schedule I." Commonwealth of Virginia. 2 December 2015. Retrieved 11 March 2016.
  7. ^ "December 2019 – WHO: World Health Organization recommends 12 NPS for scheduling".