Meptazinol

Meptazinol
Clinical data
AHFS/Drugs.com	International Drug Names
Dependence; liability	Low
Routes of; administration	Oral, IM, IV
ATC code	N02AX05 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only);
Pharmacokinetic data
Metabolism	The peak analgesic effect is seen within 30–60 minutes and lasts about 3–4 hours.
Elimination half-life	Half-Life (1.4–4 hours).
Excretion	The drug is rapidly metabolised to the glucuronide, and mostly excreted in the urine.
Identifiers
	IUPAC name (RS)-3-(3-ethyl-1-methylazepan-3-yl)phenol;
CAS Number	54340-58-8 ;
PubChem CID	41049;
ChemSpider	37469 ;
UNII	18Y7S5JKZD;
KEGG	D08182 ;
ChEMBL	ChEMBL314437 ;
CompTox Dashboard (EPA)	DTXSID6048543 ;
ECHA InfoCard	100.053.718
Chemical and physical data
Formula	C15H23NO
Molar mass	233.34922 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1cccc(c1)C2(CC)CCCCN(C)C2;
	InChI InChI=1S/C15H23NO/c1-3-15(9-4-5-10-16(2)12-15)13-7-6-8-14(17)11-13/h6-8,11,17H,3-5,9-10,12H2,1-2H3 ; Key:JLICHNCFTLFZJN-UHFFFAOYSA-N ;
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Meptazinol (trade name Meptid) is an opioid analgesic developed by Wyeth in the 1970s^[1]. Indications for use in moderate to severe pain, most commonly used to treat pain in obstetrics (childbirth). A partial µ-opioid receptor agonist, its mixed agonist/antagonist activity affords it a lower risk of dependence and abuse than full µ agonists like morphine. Meptazinol exhibits not only a short onset of action, but also a shorter duration of action relative to other opioids such as morphine, pentazocine, or buprenorphine.^[2]

References

^ US Patent 4197239
^ Holmes B, Ward A (1985). "Meptazinol. A Review of its Pharmacodynamic and Pharmacokinetic Properties and Therapeutic Efficacy". Drugs. 30 (4): 285–312. PMID 2998723.

Meptazinol at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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