|Metabolism||Hepatic (CYP2D6 and 1A2- mediated)|
|Elimination half-life||10-12 hours|
|Chemical and physical data|
|Molar mass||179.259 g/mol|
|3D model (JSmol)|
Mexiletine (INN) (sold under the trade name Mexitil) is a non-selective voltage-gated sodium channel blocker which belongs to the Class IB anti-arrhythmic group of medicines. It is used to treat arrhythmias within the heart, or seriously irregular heartbeats. It slows conduction in the heart and makes the heart tissue less sensitive. Dizziness, heartburn, nausea, nervousness, trembling, unsteadiness are common side effects. It is available in injection and capsule form.
This drug is now no longer freely available as a licensed product in the UK, although it remains available for human use in the US. Mexiletine is available to veterinarians in the US for the treatment heart disease in dogs and cats. It can be imported to the UK as an unlicensed, 'named-patient' drug.
Mexiletine may also be of use in patients experiencing refractory pain and is also effective for treating muscle stiffness resulting from myotonic dystrophy (Steinert's disease) or nondystrophic myotonias such as myotonia congenita (Thomsen disease).
- Peck T, Hill S, Williams M, eds. (2004). Pharmacology for Anaesthesia and Intensive Care (2nd ed.). Cambridge University Press. ISBN 0-521-68794-2.
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