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Clinical data
Synonyms DS-5565
CAS Number
PubChem CID
Chemical and physical data
Formula C12H19NO2
Molar mass 209.285 g/mol
3D model (JSmol)

Mirogabalin (developmental code name DS-5565) is a drug developed by Daiichi Sankyo, a gabapentinoid. Gabapentin and pregabalin are also members of this class. As a gabapentinoid, mirogabalin binds to the α2δ subunit of voltage-gated calcium channel (1 and 2), but with significantly higher potency than pregabalin. It has shown promising results in Phase II clinical trials for the treatment of diabetic peripheral neuropathic pain.[1][2]

Phase III trial results:

In Japan, the company submitted a marketing application for treatment of peripheral neuropathic pain.[5]

See also[edit]


  1. ^ Vinik, A; Rosenstock, J; Sharma, U; Feins, K; Hsu, C; Merante, D; et al. (Dec 2014). "Efficacy and safety of mirogabalin (DS-5565) for the treatment of diabetic peripheral neuropathic pain: a randomized, double-blind, placebo- and active comparator-controlled, adaptive proof-of-concept phase 2 study". Diabetes Care. 37 (12): 3253–61. doi:10.2337/dc14-1044. PMID 25231896. 
  2. ^ Vinik, A; Sharma, U; Feins, K; Hsu, C; Merante, D (2014). "DS-5565 for the Treatment Of Diabetic Peripheral Neuropathic Pain: Randomized, Double-Blind, Placebo- And Active Comparator-Controlled Phase II Study (S20.004)". Neurology. 82 (10): S20.004. 
  3. ^ "Daiichi Sankyo Announces Top-line Results from Phase 3 Global Clinical Development Program Evaluating Mirogabalin in Pain Syndromes". Daiichi Sankyo. 30 June 2017. 
  4. ^ "Daiichi Sankyo Announces Positive Top-line Results from Phase 3 Clinical Trial Evaluating Mirogabalin in Diabetic Peripheral Neuropathic Pain". Daiichi Sankyo. 31 August 2017. 
  5. ^ "Daiichi Sankyo Submits Marketing Application for Mirogabalin in Japan". Daiichi Sankyo. 15 February 2018. 

External links[edit]