microRNA 203a

MIR203A
Identifiers
Aliases	MIR203A, MIR203, MIRN203, hsa-mir-203a, miR-203, miRNA203, mir-203a, microRNA 203a
External IDs	OMIM: 611899; GeneCards: MIR203A; OMA:MIR203A - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.33 Start 104,117,405 bp End 104,117,514 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ectocervix skin of leg left ovary skin of abdomen tibial nerve vagina body of pancreas minor salivary glands monocyte subcutaneous adipose tissue n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 406986 n/a Ensembl ENSG00000207568 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 14: 104.12 – 104.12 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

MicroRNA 203a is a small RNA that in humans is encoded by the preMIR203A gene.

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into an RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Further reading

• Sonkoly E, Wei T, Janson PC, Sääf A, Lundeberg L, Tengvall-Linder M, Norstedt G, Alenius H, Homey B, Scheynius A, Ståhle M, Pivarcsi A (2007). "MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?". PLOS ONE. 2 (7): e610. Bibcode:2007PLoSO...2..610S. doi:10.1371/journal.pone.0000610. PMC 1905940. PMID 17622355.
• Lena AM, Shalom-Feuerstein R, Rivetti di Val Cervo P, Aberdam D, Knight RA, Melino G, Candi E (2008). "miR-203 represses 'stemness' by repressing DeltaNp63". Cell Death Differ. 15 (7): 1187–95. doi:10.1038/cdd.2008.69. PMID 18483491.
• Greither T, Grochola LF, Udelnow A, Lautenschläger C, Würl P, Taubert H (2010). "Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival". Int. J. Cancer. 126 (1): 73–80. doi:10.1002/ijc.24687. PMID 19551852.
• Sonkoly E, Wei T, Pavez Loriè E, Suzuki H, Kato M, Törmä H, Ståhle M, Pivarcsi A (2010). "Protein kinase C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes". J. Invest. Dermatol. 130 (1): 124–34. doi:10.1038/jid.2009.294. PMID 19759552.
• Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I, Inazawa J (2010). "miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma". Carcinogenesis. 31 (5): 766–76. doi:10.1093/carcin/bgp250. PMID 19843643.
• Melar-New M, Laimins LA (2010). "Human papillomaviruses modulate expression of microRNA 203 upon epithelial differentiation to control levels of p63 proteins". J. Virol. 84 (10): 5212–21. doi:10.1128/JVI.00078-10. PMC 2863797. PMID 20219920.
• Ikenaga N, Ohuchida K, Mizumoto K, Yu J, Kayashima T, Sakai H, Fujita H, Nakata K, Tanaka M (2010). "MicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinoma". Ann. Surg. Oncol. 17 (12): 3120–8. doi:10.1245/s10434-010-1188-8. PMID 20652642. S2CID 24422912.
• Wei T, Orfanidis K, Xu N, Janson P, Ståhle M, Pivarcsi A, Sonkoly E (2010). "The expression of microRNA-203 during human skin morphogenesis" (PDF). Exp. Dermatol. 19 (9): 854–6. doi:10.1111/j.1600-0625.2010.01118.x. PMID 20698882. S2CID 30026838.
• McKenna DJ, McDade SS, Patel D, McCance DJ (2010). "MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6". J. Virol. 84 (20): 10644–52. doi:10.1128/JVI.00703-10. PMC 2950558. PMID 20702634.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.