DNM3

DNM3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L43, 5A3F
Identifiers
Aliases	DNM3, Dyna III, dynamin 3
External IDs	OMIM: 611445; MGI: 1341299; HomoloGene: 22906; GeneCards: DNM3; OMA:DNM3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	172,418,466 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	162,305,603 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; pons; ; Brodmann area 46; ; corpus callosum; ; pars compacta; ; postcentral gyrus; ; superior vestibular nucleus; ; dorsal motor nucleus of vagus nerve; ; pars reticulata; ; orbitofrontal cortex;
	Top expressed in
	facial motor nucleus; ; anterior horn of spinal cord; ; superior colliculus; ; central gray substance of midbrain; ; inferior colliculi; ; pontine nuclei; ; medial vestibular nucleus; ; substantia nigra; ; dorsal tegmental nucleus; ; nucleus of stria terminalis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; nitric-oxide synthase binding; type 1 metabotropic glutamate receptor binding; GTP binding; type 5 metabotropic glutamate receptor binding; protein binding; hydrolase activity; GTPase activity; microtubule binding; identical protein binding; structural constituent of postsynapse;
Cellular component	cytoplasm; Golgi apparatus; postsynaptic density; photoreceptor inner segment; dendritic spine; synapse; axon; dendritic spine head; mitochondrion; perinuclear region of cytoplasm; synaptic cleft; microtubule; extracellular exosome; cytoskeleton; mitochondrial membranes; postsynaptic endocytic zone membrane; plasma membrane; membrane; cytoplasmic vesicle; postsynaptic membrane; apical tubulobulbar complex; basal tubulobulbar complex; presynapse; glutamatergic synapse;
Biological process	endocytosis; positive regulation of filopodium assembly; regulation of dendritic spine morphogenesis; negative regulation of dendritic spine morphogenesis; mitochondrial fission; dynamin family protein polymerization involved in mitochondrial fission; synapse assembly; filopodium assembly; membrane fusion; synaptic vesicle budding from presynaptic endocytic zone membrane; postsynaptic neurotransmitter receptor internalization; receptor internalization; synaptic vesicle endocytosis; regulation of synapse structure or activity; postsynapse organization; positive regulation of synaptic vesicle recycling;
	Sources:Amigo / QuickGO
Orthologs
	26052
	103967
	ENSG00000197959
	ENSMUSG00000040265
	Q9UQ16
	Q8BZ98
NM_001136127; NM_001278252; NM_015569; NM_001350204; NM_001350205;
	NM_001350206
	NM_001038619; NM_172646
NP_001129599; NP_001265181; NP_056384; NP_001337133; NP_001337134;
	NP_001337135
	NP_001033708; NP_766234
	Wikidata
View/Edit Human	View/Edit Mouse

Dynamin-3 is a protein that in humans is encoded by the DNM3 gene.^[5]^[6] The protein encoded by this gene is a member of the dynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding.^[7] DNM3 is upregulated in Sézary's syndrome.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197959 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040265 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
^ "Entrez Gene: DNM3 dynamin 3".
^ Orth JD, McNiven MA (February 2003). "Dynamin at the actin-membrane interface". Curr. Opin. Cell Biol. 15 (1): 31–9. doi:10.1016/S0955-0674(02)00010-8. PMID 12517701.
^ Booken N, Gratchev A, Utikal J, Weiss C, Yu X, Qadoumi M, Schmuth M, Sepp N, Nashan D, Rass K, Tüting T, Assaf C, Dippel E, Stadler R, Klemke CD, Goerdt S (February 2008). "Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3". Leukemia. 22 (2): 393–9. doi:10.1038/sj.leu.2405044. PMID 18033314.

External links

Overview of all the structural information available in the PDB for UniProt: Q9UQ16 (Dynamin-3) at the PDBe-KB.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197959 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040265 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10048485-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

[entrez-6] "Entrez Gene: DNM3 dynamin 3".

[pmid12517701-7] Orth JD, McNiven MA (February 2003). "Dynamin at the actin-membrane interface". Curr. Opin. Cell Biol. 15 (1): 31–9. doi:10.1016/S0955-0674(02)00010-8. PMID 12517701.

[pmid18033314-8] Booken N, Gratchev A, Utikal J, Weiss C, Yu X, Qadoumi M, Schmuth M, Sepp N, Nashan D, Rass K, Tüting T, Assaf C, Dippel E, Stadler R, Klemke CD, Goerdt S (February 2008). "Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3". Leukemia. 22 (2): 393–9. doi:10.1038/sj.leu.2405044. PMID 18033314.

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References

Further reading

External links