Jump to content

Aminophenazone

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Cydebot (talk | contribs) at 13:19, 19 April 2016 (Robot - Speedily moving category Non-steroidal anti-inflammatory drugs to Category:Nonsteroidal anti-inflammatory drugs per CFDS.). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Aminophenazone
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Pharmacokinetic data
MetabolismN-demethylation[1]
Identifiers
  • 4-Dimethylamino-1,5-dimethyl-2-phenylpyrazol-3-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.332 Edit this at Wikidata
Chemical and physical data
FormulaC13H17N3O
Molar mass231.29358 g·mol−1
3D model (JSmol)
  • O=C2\C(=C(/N(N2c1ccccc1)C)C)N(C)C
  • InChI=1S/C13H17N3O/c1-10-12(14(2)3)13(17)16(15(10)4)11-8-6-5-7-9-11/h5-9H,1-4H3 checkY
  • Key:RMMXTBMQSGEXHJ-UHFFFAOYSA-N checkY
  (verify)

Aminophenazone (or aminopyrine) is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests.[1] It is also used in measuring the total body water in the human body system.[2]

References

  1. ^ a b Caubet, M. S.; Laplante, A.; Caillé, J.; Brazier, J. L. (4 Jan 2007). "[13C]Aminopyrine and [13C]Caffeine Breath Test: Influence of Gender, Cigarette Smoking and Oral Contraceptives Intake". Isotopes in Environmental and Health Studies. 38 (2): 71–77. doi:10.1080/10256010208033314.
  2. ^ "Aminophenazone — Compound Summary". PubChem. The National Library of Medicine. 2005-03-26. Retrieved June 12, 2008. {{cite web}}: Cite has empty unknown parameter: |description= (help)