Fluticasone

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Not to be confused with fluconazole.
Fluticasone
Fluticasone.svg
Clinical data
Trade names Cutivate
AHFS/Drugs.com Monograph
Pregnancy
category
  • C for Intranasal and Inhaled
Routes of
administration
Intranasal, inhaled, topical cream or ointment
ATC code
Legal status
Legal status
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: OTC (intranasal as the propionate), Rx-only (other preparations including furoate and base intranasal)
Pharmacokinetic data
Bioavailability 0.51% (Intranasal)
Protein binding 91%
Metabolism Intranasal
Hepatic (CYP3A4-mediated)
Biological half-life 10 hours
Excretion Renal
Identifiers
Synonyms 6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
Formula C22H27F3O4S
Molar mass 444.508 g/mol
3D model (Jmol)
 NYesY (what is this?)  (verify)

Fluticasone is a synthetic glucocorticoid.[1] Both the furoate and propanoate esters, fluticasone furoate and fluticasone propionate, are used as topical anti-inflammatories[2] and inhaled corticosteroids.

References[edit]

  1. ^ Briggs, Gerald G.; Freeman, Roger K.; Yaffe, Sumner J. (2012), Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, Lippincott Williams & Wilkins, p. 600, ISBN 1451153597. 
  2. ^ Spratto, George R.; Woods, Adrienne L. (2012), Delmar Nurse's Drug Handbook 2012, Cengage Learning, p. 748, ISBN 1111310653.