Fluticasone

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Fluticasone
Fluticasone.svg
Clinical data
Trade names Cutivate, others
Synonyms 6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione; S-(Fluoromethyl)-6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate
AHFS/Drugs.com Monograph
Pregnancy
category
  • C for Intranasal and Inhaled
Routes of
administration
Intranasal, inhaled, topical cream or ointment
ATC code
Legal status
Legal status
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: OTC (intranasal as the propionate), Rx-only (other preparations including furoate and base intranasal)
Pharmacokinetic data
Bioavailability 0.51% (Intranasal)
Protein binding 91%
Metabolism Intranasal
Hepatic (CYP3A4-mediated)
Elimination half-life 10 hours
Excretion Renal
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
Formula C22H27F3O4S
Molar mass 444.508 g/mol
3D model (JSmol)
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Fluticasone is a synthetic glucocorticoid which is used in some countries to treat nasal symptoms.[1][2][3][4][5] Both the furoate and propanoate esters, fluticasone furoate and fluticasone propionate, are also used as topical anti-inflammatories[6] and inhaled corticosteroids, and are used much more commonly in comparison.[3][2][4]

References[edit]

  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 574–. ISBN 978-1-4757-2085-3. 
  2. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 1337–. ISBN 978-3-88763-075-1. 
  3. ^ a b I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 124–. ISBN 978-94-011-4439-1. 
  4. ^ a b https://www.drugs.com/international/fluticasone.html
  5. ^ Briggs, Gerald G.; Freeman, Roger K.; Yaffe, Sumner J. (2012), Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, Lippincott Williams & Wilkins, p. 600, ISBN 1451153597. 
  6. ^ Spratto, George R.; Woods, Adrienne L. (2012), Delmar Nurse's Drug Handbook 2012, Cengage Learning, p. 748, ISBN 1111310653.