Fluticasone
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| Clinical data | |
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| Trade names | Cutivate, others |
| Synonyms | 6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione; S-(Fluoromethyl)-6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | Intranasal, inhaled, topical cream or ointment |
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| Pharmacokinetic data | |
| Bioavailability | 0.51% (Intranasal) |
| Protein binding | 91% |
| Metabolism |
Intranasal Hepatic (CYP3A4-mediated) |
| Elimination half-life | 10 hours |
| Excretion | Renal |
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| Chemical and physical data | |
| Formula | C22H27F3O4S |
| Molar mass | 444.508 g/mol |
| 3D model (JSmol) | |
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  (what is this?) (verify) | |
Fluticasone is a synthetic glucocorticoid which is used in some countries to treat nasal symptoms.[1][2][3][4][5] Both the furoate and propanoate esters, fluticasone furoate and fluticasone propionate, are also used as topical anti-inflammatories[6] and inhaled corticosteroids, and are used much more commonly in comparison.[3][2][4]
References[edit]
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 574–. ISBN 978-1-4757-2085-3.
- ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 1337–. ISBN 978-3-88763-075-1.
- ^ a b I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 124–. ISBN 978-94-011-4439-1.
- ^ a b https://www.drugs.com/international/fluticasone.html
- ^ Briggs, Gerald G.; Freeman, Roger K.; Yaffe, Sumner J. (2012), Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, Lippincott Williams & Wilkins, p. 600, ISBN 1451153597.
- ^ Spratto, George R.; Woods, Adrienne L. (2012), Delmar Nurse's Drug Handbook 2012, Cengage Learning, p. 748, ISBN 1111310653.
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