GNB1

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GNB1
Protein GNB1 PDB 1a0r.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GNB1, G protein subunit beta 1, MRD42
External IDs MGI: 95781 HomoloGene: 55532 GeneCards: GNB1
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GNB1
Genomic location for GNB1
Band 1p36.33 Start 1,785,285 bp[1]
End 1,891,117 bp[1]
RNA expression pattern
PBB GE GNB1 200746 s at fs.png

PBB GE GNB1 200744 s at fs.png

PBB GE GNB1 200745 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002074
NM_001282538
NM_001282539

NM_001160016
NM_001160017
NM_008142

RefSeq (protein)

NP_001269467
NP_001269468
NP_002065

NP_001153488
NP_001153489
NP_032168

Location (UCSC) Chr 1: 1.79 – 1.89 Mb Chr 1: 155.49 – 155.56 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene.[5]

Function[edit]

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.[5]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article
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NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article
|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602". 

Interactions[edit]

GNB1 has been shown to interact with GNG4.[6][7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000078369 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029064 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1". 
  6. ^ Ray K, Kunsch C, Bonner LM, Robishaw JD (September 1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765–71. PMID 7665596. doi:10.1074/jbc.270.37.21765. 
  7. ^ Yan K, Kalyanaraman V, Gautam N (March 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. PMID 8636150. doi:10.1074/jbc.271.12.7141. 

Further reading[edit]