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Guanine nucleotide binding protein (G protein), beta polypeptide 2
Protein GNB2 PDB 1b9x.png
PDB rendering based on 1b9x.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol GNB2
External IDs OMIM139390 MGI95784 HomoloGene68451 GeneCards: GNB2 Gene
RNA expression pattern
PBB GE GNB2 200852 x at tn.png
More reference expression data
Species Human Mouse
Entrez 2783 14693
Ensembl ENSG00000172354 ENSMUSG00000029713
UniProt P62879 P62880
RefSeq (mRNA) NM_005273 NM_010312
RefSeq (protein) NP_005264 NP_034442
Location (UCSC) Chr 7:
100.67 – 100.68 Mb
Chr 5:
137.53 – 137.53 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 is a protein that in humans is encoded by the GNB2 gene.[1][2]

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR.[2]


Further reading[edit]