Arginine kinase

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arginine kinase
Identifiers
EC number2.7.3.3
CAS number9026-70-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, arginine kinase (EC 2.7.3.3) is an enzyme that catalyzes the chemical reaction

ATP + L-arginine ADP + Nω-phospho-L-arginine

Thus, the two substrates of this enzyme are ATP and L-arginine, whereas its two products are ADP and Nω-phospho-L-arginine.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a nitrogenous group as acceptor. The systematic name of this enzyme class is ATP:L-arginine Nω-phosphotransferase. Other names in common use include arginine phosphokinase, adenosine 5'-triphosphate: L-arginine phosphotransferase, adenosine 5'-triphosphate-arginine phosphotransferase, ATP:L-arginine N-phosphotransferasel ATP:L-arginine, and ω-N-phosphotransferase. This enzyme participates in arginine and proline metabolism.

Structural studies[edit]

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1BG0​, 1M15​, 1M80​, 1P50​, 1P52​, 1RL9​, 1SD0​, and 2J1Q​.

References[edit]

  • ELODI P, SZORENYI E (1956). "Properties of crystalline arginine-phosphoferase isolated from Crustacean muscle". Acta Physiol. Hung. 9 (4): 367–79. PMID 13339436.
  • MORRISON JF, GRIFFITHS DE, ENNOR AH (1957). "The purification and properties of arginine phosphokinase". Biochem. J. 65 (1): 143–53. PMC 1199841. PMID 13403885.
  • Z; Fancsovits, P; Akos, M; Tóthné Gilán, Z; Hauzman, E; Papp, Z (2006). "[In vitro fertilization at our department. A decade's work in figures and facts (1994-2003)]". Orv. Hetil. 147 (1): 7–14. PMID 16519065.
  • VIRDEN R, WATTS DC, BALDWIN E (1965). "Adenosine 5′-triphosphate–arginine phosphotransferase from lobster muscle: purification and properties". Biochem. J. 94 (3): 536–44. PMC 1206586. PMID 14340045.