mir-BHRF1-2 microRNA precursor family
| mir-BHRF1-2 microRNA precursor family | |
|---|---|
 Predicted secondary structure and sequence conservation of mir-BHRF1-2 | |
| Identifiers | |
| Symbol | mir-BHRF1-2 |
| Rfam | RF00366 |
| miRBase | MI0001065 |
| miRBase family | MIPF0000332 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Viruses |
| GO | GO:0035195 GO:0035068 |
| SO | SO:0001244 |
| PDB structures | PDBe |
The mir-BHRF1-2 microRNA precursor found in human herpesvirus 4 (Epstein-Barr virus), cercopithicine herpesvirus 15 and herpesvirus papio. In Epstein-Barr virus, mir-BHRF1-2 is found in the 3' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog. The mature sequence is excised from the 3' arm of the hairpin.[1] Two other miRNA precursors were found in this reading frame, namely Mir-BHRF1-1 and Mir-BHRF1-3.[1]
BHRF-1-2 miRNA is thought to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein-Barr virus genome.[2] BHRF-1-2 has been shown to be expressed in latency-III infected lymphoblasts.[3]
References
- ^ a b Pfeffer, S; Zavolan M; Grasser FA; Chien M; Russo JJ; Ju J; John B; Enright AJ; Marks D; Sander C; Tuschl T (2004). "Identification of Virus-Encoded MicroRNAs". Science. 304 (5671): 734–736. doi:10.1126/science.1096781. PMID 15118162.
- ^ Feederle, R; Haar, J; Bernhardt, K; Linnstaedt, SD; Bannert, H; Lips, H; Cullen, BR; Delecluse, HJ (Jul 13, 2011). "The members of a viral miRNA cluster co-operate to transform B lymphocytes". Journal of Virology. 85 (19): 9801–10. doi:10.1128/JVI.05100-11. PMC 3196389. PMID 21752900.
- ^ Xing, L; Kieff, E (September 2007). "Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication". Journal of Virology. 81 (18): 9967–75. doi:10.1128/JVI.02244-06. PMC 2045418. PMID 17626073.
External links
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