Richard Henderson (biologist)
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Starting in 1975 with Nigel Unwin, Henderson studied the structure of the membrane protein bacteriorhodopsin (bR) by electron microscopy. A seminal paper in Nature by Henderson and Unwin (1975) established a low resolution structural model for bR showing the protein to consist of 7 transmembrane helices. This paper was important for a number of reasons, not the least of which was that it showed that membrane proteins had well defined structures and that transmembrane alpha-helices could occur. After 1975 Henderson worked without Unwin on the structure of bR.
In 1990 Henderson published an atomic model of bR by electron crystallography in the Journal of Molecular Biology. This model was the second ever atomic model of a membrane protein. The techniques Henderson developed for electron crystallography are still in use. More recently, Dr. Henderson has devoted his attention to single particle electron microscopy: he was an early proponent of the idea that single particle EM is capable of determining atomic resolution models for proteins, explained in a 1995 paper in Quarterly Reviews of Biophysics. He made seminal contributions to many of the approaches used in single particle EM, including pioneering the development of direct electron detectors that recently allowed single particle cryo-EM to achieve this goal.
Although Henderson typically worked independently, he trained a number of scientists who have gone on to independent research careers. These scientists include:
David Agard, now at UCSF
Per Bullough, now at Sheffield
Nikolaus Grigorieff, now at HHMI Janelia Research Campus
Reinhard Grisshammer, now at NIH
Edmund Kunji, now at MRC MBU
Peter Rosenthal, now at MRC NIMR
John Rubinstein, now at SickKids Research Institute
Gebhard Schertler, now at ETH Paul Scherrer Institute
Christopher Tate, now at MRC Laboratory of Molecular Biology
Vincenz Unger, now at Northwestern University
Henderson was educated at Boroughmuir High School and Edinburgh University (B.Sc. Hons in Physics, 1st Class). He completed his PhD research under the supervision of David Blow at the Medical Research Council Laboratory of Molecular Biology and received the degree from Cambridge University in 1969. He has worked at the Medical Research Council's Laboratory of Molecular Biology (MRC LMB) in Cambridge since 1973, and was its director between 1996 and 2006.
- 1978 Awarded the William Bate Hardy Prize
- 1983 Elected a Fellow of the Royal Society
- 1984 Awarded the Sir Hans Krebs Medal by the Federation of European Biochemical Societies
- 1998 Elected a Foreign Associate of the US National Academy of Sciences
- 1981 Awarded the Ernst-Ruska Prize for Electron Microscopy
- 1991 Awarded the Lewis S. Rosenstiel Award
- 1993 Awarded the Louis-Jeantet Prize for Medicine
- 1999 Awarded the Gregori Aminoff prize (together with Nigel Unwin)
- 2003 Hon. Fellow Corpus Christi College Cambridge
- 2003 Hon. Member British Biophysical Society
- 2005 Awarded Distinguished Scientist Award and Fellow, Microscopy Society of America
- 2008 Hon. D. Sc. Edinburgh University
- 2016 Awarded the Copley Medal of the Royal Society
- 2016 Awarded the Alexander Hollaender Award in Biophysics
- CV of Richard Henderson
- Announcement of Newly Elected Honorary Members" from the British Biophysical Society
- Copley Medal 2016
- HENDERSON, Dr Richard, Who's Who 2014, A & C Black,2014; online edn, Oxford University Press, 2014
- "Three-Dimensional Model of Purple Membrane Obtained by Electron Microscopy". Nature. 257: 28–32. doi:10.1038/257028a0.
- "Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy.". Journal of Molecular Biology. 213: 899–929. doi:10.1016/S0022-2836(05)80271-2.
- Henderson, R (February 2004). "Realizing the potential of electron cryo-microscopy.". Q. Rev. Biophys. 37: 3–13. doi:10.1017/S0033583504003920. PMID 17390603.