Wang Bi's most important works are commentaries on Laozi's Tao Te Ching and the I Ching. The text of the Tao Te Ching that appeared with his commentary was widely considered the best copy of his work until the discovery of the Han-era Mawangdui texts in 1973. He was a scholar of xuanxue.
Wang served as a minor bureaucrat in the state of Cao Wei during the Three Kingdoms period. He was married with a daughter when he died of sickness at the age of 23.