Wang Bi's most important works are commentaries on Laozi's Tao Te Ching and the I Ching. The text of the Tao Te Ching that appeared with his commentary was widely considered the best copy of his work until the discovery of the Mawangdui Han tomb texts in 1973. He was a scholar of xuanxue.
Wang served as a minor bureaucrat in the state of Cao Wei during the Three Kingdoms period. He was married with a daughter when he died of sickness at the age of 23.