Vesamicol: Difference between revisions
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'''Vesamicol''' is an experimental drug, acting [[presynaptic]]ally on [[acetylcholine]] (ACh) synthesis. |
'''Vesamicol''' is an experimental drug, acting [[presynaptic]]ally on [[acetylcholine]] (ACh) synthesis.<ref name="pmid8619013">{{cite journal |author=Salin-Pascual RJ, Jimenez-Anguiano A |title=Vesamicol, an acetylcholine uptake blocker in presynaptic vesicles, suppresses rapid eye movement (REM) sleep in the rat |journal=Psychopharmacology |volume=121 |issue=4 |pages=485–7 |year=1995 |month=October |pmid=8619013 |doi= |url=}}</ref> |
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==Mechanism of action== |
==Mechanism of action== |
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==References== |
==References== |
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{{R.Z. Salin-Pascual and A.Jimenez-Anguiano, Vesamicol, an acetylcholine uptake blocker in presynaptic vesicles, suppresses rapid eye movement (REM) sleep in the rat Psychopharlnacology (1995) 121:485-487}} |
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{{Anticholinergics}} |
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[[Category:Piperidines]] |
[[Category:Piperidines]] |
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Revision as of 20:14, 4 October 2008
Vesamicol is an experimental drug, acting presynaptically on acetylcholine (ACh) synthesis.[1]
Mechanism of action
Vesamicol can be broadly categorized as a cholinergic physiological antagonist, because it reduces the apparent activity of cholinergic neurons, but does not act at the post-synaptic ACh receptor. Vesamicol causes a non-competitive and reversible block of the intracellular transporter responsible for carrying newly synthesised ACh into storage vesicles in the pre-synaptic nerve terminal. This transport process is driven by a proton gradient between cell organelles and the cytoplasm.
References
- ^ Salin-Pascual RJ, Jimenez-Anguiano A (1995). "Vesamicol, an acetylcholine uptake blocker in presynaptic vesicles, suppresses rapid eye movement (REM) sleep in the rat". Psychopharmacology. 121 (4): 485–7. PMID 8619013.
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