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ATPase, Na+/K+ transporting, alpha 4 polypeptide
Symbols ATP1A4 ; ATP1A1; ATP1AL2
External IDs OMIM607321 HomoloGene113769 IUPHAR: 836 ChEMBL: 4053 GeneCards: ATP1A4 Gene
EC number
RNA expression pattern
PBB GE ATP1A4 gnf1h01969 at tn.png
More reference expression data
Species Human Mouse
Entrez 480 27222
Ensembl ENSG00000132681 ENSMUSG00000007107
UniProt Q13733 Q9WV27
RefSeq (mRNA) NM_001001734 NM_013734
RefSeq (protein) NP_001001734 NP_038762
Location (UCSC) Chr 1:
160.12 – 160.16 Mb
Chr 1:
172.22 – 172.26 Mb
PubMed search [1] [2]

Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.[1][2][3]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]


  1. ^ Buetow KH, Nishimura D, Nakamura Y, Jiang O, Murray JC (May 1991). "A detailed multipoint gene map of chromosome 1q". Genomics 8 (1): 13–21. doi:10.1016/0888-7543(90)90220-O. PMID 1981991. 
  2. ^ Shull MM, Lingrel JB (Jul 1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proc Natl Acad Sci U S A 84 (12): 4039–43. doi:10.1073/pnas.84.12.4039. PMC 305017. PMID 3035563. 
  3. ^ a b "Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide". 

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