From Wikipedia, the free encyclopedia
Jump to: navigation, search
"Rac2" redirects here. For the second game in the Ratchet & Clank series, see Ratchet & Clank: Going Commando.
Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
Protein RAC2 PDB 1ds6.png
PDB rendering based on 1ds6.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RAC2 ; EN-7; Gx; HSPC022; p21-Rac2
External IDs OMIM602049 MGI97846 HomoloGene55699 ChEMBL: 5581 GeneCards: RAC2 Gene
RNA expression pattern
PBB GE RAC2 213603 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5880 19354
Ensembl ENSG00000128340 ENSMUSG00000033220
UniProt P15153 Q05144
RefSeq (mRNA) NM_002872 NM_009008
RefSeq (protein) NP_002863 NP_033034
Location (UCSC) Chr 22:
37.62 – 37.64 Mb
Chr 15:
78.56 – 78.57 Mb
PubMed search [1] [2]

Rac2 (Ras-related C3 botulinum toxin substrate 2) is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[1] It is encoded by the gene RAC2.[2]

Members of Rho family of GTPases appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.[2]


Rac2 has been shown to interact with ARHGDIA[3][4] and Nitric oxide synthase 2A.[5]

See also[edit]


  1. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823. 
  2. ^ a b "Entrez Gene: RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)". 
  3. ^ Gorvel, J P; Chang T C; Boretto J; Azuma T; Chavrier P (January 1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity". FEBS Lett. (NETHERLANDS) 422 (2): 269–73. doi:10.1016/S0014-5793(98)00020-9. ISSN 0014-5793. PMID 9490022. 
  4. ^ Fauré, J; Dagher M C (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie (France) 83 (5): 409–14. doi:10.1016/S0300-9084(01)01263-9. ISSN 0300-9084. PMID 11368848. 
  5. ^ Kuncewicz, T; Balakrishnan P; Snuggs M B; Kone B C (August 2001). "Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages". Am. J. Physiol. Renal Physiol. (United States) 281 (2): F326–36. ISSN 0363-6127. PMID 11457725. 

Further reading[edit]

External links[edit]