RAC2

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Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
Protein RAC2 PDB 1ds6.png
PDB rendering based on 1ds6.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RAC2 ; EN-7; Gx; HSPC022; p21-Rac2
External IDs OMIM602049 MGI97846 HomoloGene55699 ChEMBL: 5581 GeneCards: RAC2 Gene
RNA expression pattern
PBB GE RAC2 213603 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5880 19354
Ensembl ENSG00000128340 ENSMUSG00000033220
UniProt P15153 Q05144
RefSeq (mRNA) NM_002872 NM_009008
RefSeq (protein) NP_002863 NP_033034
Location (UCSC) Chr 22:
37.62 – 37.64 Mb
Chr 15:
78.56 – 78.57 Mb
PubMed search [1] [2]

Rac2 (Ras-related C3 botulinum toxin substrate 2) is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[1] It is encoded by the gene RAC2.[2]

Members of Rho family of GTPases appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.[2]

Interactions[edit]

Rac2 has been shown to interact with ARHGDIA[3][4] and Nitric oxide synthase 2A.[5]

See also[edit]

References[edit]

  1. ^ Ridley AJ (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. PMID 16949823. 
  2. ^ a b "Entrez Gene: RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)". 
  3. ^ Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P (January 1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity". FEBS Lett. 422 (2): 269–73. doi:10.1016/S0014-5793(98)00020-9. PMID 9490022. 
  4. ^ Fauré J, Dagher MC (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie 83 (5): 409–14. doi:10.1016/S0300-9084(01)01263-9. PMID 11368848. 
  5. ^ Kuncewicz T, Balakrishnan P, Snuggs MB, Kone BC (August 2001). "Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages". Am. J. Physiol. Renal Physiol. 281 (2): F326–36. PMID 11457725. 

Further reading[edit]

  • Mizuno T, Kaibuchi K, Ando S, Musha T, Hiraoka K, Takaishi K et al. (1992). "Regulation of the superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins". J. Biol. Chem. 267 (15): 10215–8. PMID 1316893. 
  • Reibel L, Dorseuil O, Stancou R, Bertoglio J, Gacon G (1991). "A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation". Biochem. Biophys. Res. Commun. 175 (2): 451–8. doi:10.1016/0006-291X(91)91585-Z. PMID 1902092. 
  • Kinsella BT, Erdman RA, Maltese WA (1991). "Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA". J. Biol. Chem. 266 (15): 9786–94. PMID 1903399. 
  • Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R (1989). "rac, a novel ras-related family of proteins that are botulinum toxin substrates". J. Biol. Chem. 264 (28): 16378–82. PMID 2674130. 
  • Kwong CH, Malech HL, Rotrosen D, Leto TL (1993). "Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins". Biochemistry 32 (21): 5711–7. doi:10.1021/bi00072a029. PMID 8504089. 
  • Courjal F, Chuchana P, Theillet C, Fort P (1997). "Structure and chromosomal assignment to 22q12 and 17qter of the ras-related Rac2 and Rac3 human genes". Genomics 44 (2): 242–6. doi:10.1006/geno.1997.4871. PMID 9299243. 
  • Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P (1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity". FEBS Lett. 422 (2): 269–73. doi:10.1016/S0014-5793(98)00020-9. PMID 9490022. 
  • Dai Q, Choy E, Chiu V, Romano J, Slivka SR, Steitz SA et al. (1998). "Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum". J. Biol. Chem. 273 (24): 15030–4. doi:10.1074/jbc.273.24.15030. PMID 9614111. 
  • Ahmed S, Prigmore E, Govind S, Veryard C, Kozma R, Wientjes FB et al. (1998). "Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox)". J. Biol. Chem. 273 (25): 15693–701. doi:10.1074/jbc.273.25.15693. PMID 9624165. 
  • Faris SL, Rinckel LA, Huang J, Hong YR, Kleinberg ME (1998). "Phagocyte NADPH oxidase p67-phox possesses a novel carboxylterminal binding site for the GTPases Rac2 and Cdc42". Biochem. Biophys. Res. Commun. 247 (2): 271–6. doi:10.1006/bbrc.1998.8775. PMID 9642115. 
  • Zhang B, Zheng Y (1998). "Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation". J. Biol. Chem. 273 (40): 25728–33. doi:10.1074/jbc.273.40.25728. PMID 9748241. 
  • Nishihara H, Kobayashi S, Hashimoto Y, Ohba F, Mochizuki N, Kurata T et al. (1999). "Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins". Biochim. Biophys. Acta 1452 (2): 179–87. doi:10.1016/S0167-4889(99)00133-0. PMID 10559471. 
  • Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Scheffzek K, Stephan I, Jensen ON, Illenberger D, Gierschik P (2000). "The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI". Nat. Struct. Biol. 7 (2): 122–6. doi:10.1038/72392. PMID 10655614. 
  • Ambruso DR, Knall C, Abell AN, Panepinto J, Kurkchubasche A, Thurman G et al. (2000). "Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4654–9. doi:10.1073/pnas.080074897. PMC 18288. PMID 10758162. 
  • Williams DA, Tao W, Yang F, Kim C, Gu Y, Mansfield P et al. (2000). "Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency". Blood 96 (5): 1646–54. PMID 10961859. 
  • Tamura M, Kai T, Tsunawaki S, Lambeth JD, Kameda K (2000). "Direct interaction of actin with p47(phox) of neutrophil NADPH oxidase". Biochem. Biophys. Res. Commun. 276 (3): 1186–90. doi:10.1006/bbrc.2000.3598. PMID 11027608. 
  • Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ et al. (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. 
  • Lapouge K, Smith SJ, Walker PA, Gamblin SJ, Smerdon SJ, Rittinger K (2000). "Structure of the TPR domain of p67phox in complex with Rac.GTP". Mol. Cell 6 (4): 899–907. doi:10.1016/S1097-2765(05)00091-2. PMID 11090627. 
  • Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ et al. (2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801. 

External links[edit]