Eukaryotic elongation factors
From Wikipedia, the free encyclopedia
Eukaryotic elongation factors are very similar to those in prokaryotes.
Elongation in eukaryotes is carried out with two elongation factors: eEF-1 and eEF-2.
- The first is eEF-1, and has two subunits, α and βγ. α acts as counterpart to prokaryotic EF-Tu, mediating the entry of the aminoacyl tRNA into a free site of the ribosome. βγ acts as counterpart to prokaryotic EF-Ts, serving as the guanine nucleotide exchange factor for α, catalyzing the release of GDP from α.
- The second elongation factor is eEF-2, the counterpart to prokaryotic EF-G, catalyzing the translocation of the tRNA and mRNA down the ribosome at the end of each round of polypeptide elongation.
[edit] External links
- nobelprize.org Explaining the function of eukaryotic elongation factors
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| Ribosomal proteins |
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aIF1 · aIF2 · aIF5 · aIF6
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eIF1 (EIF1AX, AY, 1B)
eIF2 (EIF2S1, EIF2S2, EIF2S3) · EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5 · EIF-2 kinase
eIF3 (EIF3A, B, C, D, F, G, H, I, J, K, M, S6)
eIF4 (EIF4A2, A3, B, E1, E2, G1, G2, G3, H)
eIF5 (EIF5A, A2, B)
eIF6 (EIF6)
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Other
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| Other concepts |
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see also disorders of translation and posttranslational modification
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)
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| 3.6.1 |
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| 3.6.2 |
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| 3.6.3-4: ATPase |
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| 3.6.5: GTPase |
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Rho family of GTPases: Cdc42 (CDC42, TC10, TCL) • RhoUV (RhoU, RhoV) • Rac (Rac1, 2, 3, RhoG) • RhoBTB (1, 2) • RhoH • Rho (A, B, C) • Rnd (1, 2, 3) • RhoDF (RhoF, RhoD)
other: Ras ( HRAS, KRAS, NRAS) · Rab ( RAB23, RAB27) · Arf ( ARF6, SAR1B, ARL13B, ARL6) · Ran · Rheb · Rap
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