Eukaryotic elongation factors

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Eukaryotic elongation factors are very similar to those in prokaryotes.

Elongation in eukaryotes is carried out with two elongation factors: eEF-1 and eEF-2.

  • The first is eEF-1, and has two subunits, α and βγ. α acts as counterpart to prokaryotic EF-Tu, mediating the entry of the aminoacyl tRNA into a free site of the ribosome. βγ acts as counterpart to prokaryotic EF-Ts, serving as the guanine nucleotide exchange factor for α, catalyzing the release of GDP from α.
  • The second elongation factor is eEF-2, the counterpart to prokaryotic EF-G, catalyzing the translocation of the tRNA and mRNA down the ribosome at the end of each round of polypeptide elongation.

External links[edit]

  • nobelprize.org Explaining the function of eukaryotic elongation factors