Butyrate
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Butyrate is the traditional name for the conjugate base of butanoic acid (old name butyric acid). The formula of the butanoate ion is C4H7O2-. The archaic name is used as part of the name of butyrates or butanoates, or esters and salts of butyric acid, a short chain fatty acid. Examples include
- Cellulose acetate butyrate, an aircraft dope
- Methyl butyrate
- Ethyl butyrate
- Butyl butyrate
- Pentyl butyrate
- Sodium butyrate a HDAC inhibitor used in psychiatry
Butyrates are important as food for cells lining the mammalian colon (colonocytes). Without butyrates for energy, colon cells undergo autophagy (self digestion) and die.[1]
[edit] References
- ^ Donohoe, Dallas R.; Garge, Nikhil; Zhang, Xinxin; Sun, Wei; O'Connell, Thomas M.; Bunger, Maureen K.; Bultman, Scott J. (2011). "The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon". Cell Metabolism 13 (5): 517–26. doi:10.1016/j.cmet.2011.02.018. PMC 3099420. PMID 21531334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3099420.
