FUT8

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Fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
Protein FUT8 PDB 2de0.png
PDB rendering based on 2de0.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FUT8 ; MGC26465
External IDs OMIM602589 MGI1858901 HomoloGene9650 GeneCards: FUT8 Gene
EC number 2.4.1.68
RNA expression pattern
PBB GE FUT8 203988 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2530 53618
Ensembl ENSG00000033170 ENSMUSG00000021065
UniProt Q9BYC5 Q9WTS2
RefSeq (mRNA) NM_004480 NM_001252614
RefSeq (protein) NP_004471 NP_001239543
Location (UCSC) Chr 14:
65.88 – 66.21 Mb
Chr 12:
77.24 – 77.48 Mb
PubMed search [1] [2]

Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.[1][2]

This enzyme belongs to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternatively spliced variants encoding different isoforms have been identified.[2]

References[edit]

  1. ^ Costache M, Apoil PA, Cailleau A, Elmgren A, Larson G, Henry S, Blancher A, Iordachescu D, Oriol R, Mollicone R (Dec 1997). "Evolution of fucosyltransferase genes in vertebrates". J Biol Chem 272 (47): 29721–8. doi:10.1074/jbc.272.47.29721. PMID 9368041. 
  2. ^ a b "Entrez Gene: FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)". 

Further reading[edit]