XYLT2

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Xylosyltransferase II
Identifiers
Symbols XYLT2 ; PXYLT2; XT-II; XT2; xylT-II
External IDs OMIM608125 MGI2444797 HomoloGene23349 GeneCards: XYLT2 Gene
EC number 2.4.2.26
RNA expression pattern
PBB GE XYLT2 219401 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 64132 217119
Ensembl ENSG00000015532 ENSMUSG00000020868
UniProt Q9H1B5 Q9EPL0
RefSeq (mRNA) NM_022167 NM_145828
RefSeq (protein) NP_071450 NP_665827
Location (UCSC) Chr 17:
48.42 – 48.44 Mb
Chr 11:
94.66 – 94.68 Mb
PubMed search [1] [2]

Xylosyltransferase 2 is an enzyme that in humans is encoded by the XYLT2 gene.[1][2]

The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis.[2]

References[edit]

  1. ^ Gotting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K (Jan 2001). "Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II". J Mol Biol 304 (4): 517–28. doi:10.1006/jmbi.2000.4261. PMID 11099377. 
  2. ^ a b "Entrez Gene: XYLT2 xylosyltransferase II". 

Further reading[edit]