HAS1

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Hyaluronan synthase 1
Identifiers
Symbols HAS1 ; HAS
External IDs OMIM601463 MGI106590 HomoloGene1165 GeneCards: HAS1 Gene
EC number 2.4.1.212
RNA expression pattern
PBB GE HAS1 207316 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3036 15116
Ensembl ENSG00000105509 ENSMUSG00000003665
UniProt Q92839 Q61647
RefSeq (mRNA) NM_001297436 NM_008215
RefSeq (protein) NP_001284365 NP_032241
Location (UCSC) Chr 19:
52.22 – 52.23 Mb
Chr 17:
17.84 – 17.86 Mb
PubMed search [1] [2]

Hyaluronan synthase 1 is an enzyme that in humans is encoded by the HAS1 gene.[1][2]

Structure[edit]

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded via ABC-transporter into the extracellular space.[3]

Function[edit]

It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.[2]

References[edit]

  1. ^ Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID 9169154. 
  2. ^ a b "Entrez Gene: HAS1 hyaluronan synthase 1". 
  3. ^ Schulz T, Schumacher U, Prehm P (July 2007). "Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP". J. Biol. Chem. 282 (29): 20999–1004. doi:10.1074/jbc.M700915200. PMID 17540771. 


Further reading[edit]