UGT1A10

From Wikipedia, the free encyclopedia
Jump to: navigation, search
UDP glucuronosyltransferase 1 family, polypeptide A10
Identifiers
Symbols UGT1A10 ; UDPGT; UGT-1J; UGT1-10; UGT1.10; UGT1J
External IDs OMIM606435 MGI3580642 HomoloGene133281 ChEMBL: 1743320 GeneCards: UGT1A10 Gene
EC number 2.4.1.17
Orthologs
Species Human Mouse
Entrez 54575 394430
Ensembl ENSG00000242515 ENSMUSG00000090165
UniProt Q9HAW8 D3Z7G0
RefSeq (mRNA) NM_019075 NM_201641
RefSeq (protein) NP_061948 NP_964003
Location (UCSC) Chr 2:
234.55 – 234.68 Mb
Chr 1:
88.06 – 88.22 Mb
PubMed search [1] [2]

UDP-glucuronosyltransferase 1-10 is an enzyme that in humans is encoded by the UGT1A10 gene.[1][2][3]

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.[3]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

[[File:
IrinotecanPathway_WP46359 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
IrinotecanPathway_WP46359 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article
|{{{bSize}}}px]]
Irinotecan Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP46359". 

References[edit]

  1. ^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (Oct 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054. 
  2. ^ Mojarrabi B, Mackenzie PI (Oct 1997). "The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid". Biochem Biophys Res Commun 238 (3): 775–8. doi:10.1006/bbrc.1997.7388. PMID 9325166. 
  3. ^ a b "Entrez Gene: UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10". 

Further reading[edit]