FUT9

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
Identifiers
Symbols FUT9 ; Fuc-TIX
External IDs OMIM606865 MGI1330859 HomoloGene4800 ChEMBL: 4985 GeneCards: FUT9 Gene
EC number 2.4.1.152
RNA expression pattern
PBB GE FUT9 207696 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10690 14348
Ensembl ENSG00000172461 ENSMUSG00000055373
UniProt Q9Y231 O88819
RefSeq (mRNA) NM_006581.3 NM_010243.3
RefSeq (protein) NP_006572.2 NP_034373.1
Location (UCSC) Chr 6:
96.46 – 96.65 Mb
Chr 4:
25.54 – 25.73 Mb
PubMed search [1] [2]

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT9 gene.[1][2][3]

FUT9 is one of several alpha-3-fucosyltransferases that can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides. FUT9 synthesizes the LeX oligosaccharide (CD15), which is expressed in organ buds progressing in mesenchyma during human embryogenesis.[supplied by OMIM][3]

References[edit]

  1. ^ Kaneko M, Kudo T, Iwasaki H, Ikehara Y, Nishihara S, Nakagawa S, Sasaki K, Shiina T, Inoko H, Saitou N, Narimatsu H (Jul 1999). "Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX". FEBS Lett 452 (3): 237–42. doi:10.1016/S0014-5793(99)00640-7. PMID 10386598. 
  2. ^ Kaneko M, Kudo T, Iwasaki H, Shiina T, Inoko H, Kozaki T, Saitou N, Narimatsu H (Jan 2000). "Assignment of the human alpha 1,3-fucosyltransferase IX gene (FUT9) to chromosome band 6q16 by in situ hybridization". Cytogenet Cell Genet 86 (3–4): 329–30. doi:10.1159/000015329. PMID 10575236. 
  3. ^ a b "Entrez Gene: FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)". 

Further reading[edit]