UGT2B17

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UDP glucuronosyltransferase 2 family, polypeptide B17
Identifiers
Symbols UGT2B17 ; BMND12; UDPGT2B17
External IDs OMIM601903 MGI1919023 HomoloGene68144 ChEMBL: 4978 GeneCards: UGT2B17 Gene
EC number 2.4.1.17
RNA expression pattern
PBB GE UGT2B17 207245 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7367 71773
Ensembl ENSG00000197888 ENSMUSG00000035836
UniProt O75795 Q3UWB9
RefSeq (mRNA) NM_001077 NM_152811
RefSeq (protein) NP_001068 NP_690024
Location (UCSC) Chr 4:
69.4 – 69.43 Mb
Chr 5:
86.92 – 86.93 Mb
PubMed search [1] [2]

UDP-glucuronosyltransferase 2B17 is an enzyme that in humans is encoded by the UGT2B17 gene.[1][2]

UGT2B17 belongs to the family of UDP-glucuronosyltransferases (UGTs; EC 2.4.1.17), enzymes that catalyze the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a variety of substrates, including steroid hormones.[supplied by OMIM][2]

References[edit]

  1. ^ Beaulieu M, Levesque E, Hum DW, Belanger A (Nov 1996). "Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids". J Biol Chem 271 (37): 22855–62. doi:10.1074/jbc.271.37.22855. PMID 8798464. 
  2. ^ a b "Entrez Gene: UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17". 

Further reading[edit]

  • Chung LW, Coffey DS (1978). "Androgen glucuronide. II. DIfferences in its formation by human normal and benign hyperplastic prostates.". Investigative urology 15 (5): 385–8. PMID 76619. 
  • Moghissi E, Ablan F, Horton R (1984). "Origin of plasma androstanediol glucuronide in men.". J. Clin. Endocrinol. Metab. 59 (3): 417–21. doi:10.1210/jcem-59-3-417. PMID 6746859. 
  • Beaulieu M, Lévesque E, Tchernof A, et al. (1997). "Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme.". DNA Cell Biol. 16 (10): 1143–54. doi:10.1089/dna.1997.16.1143. PMID 9364925. 
  • Collier AC, Ganley NA, Tingle MD, et al. (2002). "UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term.". Biochem. Pharmacol. 63 (3): 409–19. doi:10.1016/S0006-2952(01)00890-5. PMID 11853692. 
  • Chouinard S, Pelletier G, Bélanger A, Barbier O (2005). "Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium.". Endocr. Res. 30 (4): 717–25. doi:10.1081/ERC-200044014. PMID 15666817. 
  • Lazarus P, Zheng Y, Aaron Runkle E, et al. (2006). "Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes.". Pharmacogenet. Genomics 15 (11): 769–78. doi:10.1097/01.fpc.0000175596.52443.ef. PMID 16220109. 
  • Jakobsson J, Ekström L, Inotsume N, et al. (2006). "Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism.". J. Clin. Endocrinol. Metab. 91 (2): 687–93. doi:10.1210/jc.2005-1643. PMID 16332934. 
  • Park J, Chen L, Ratnashinge L, et al. (2006). "Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men.". Cancer Epidemiol. Biomarkers Prev. 15 (8): 1473–8. doi:10.1158/1055-9965.EPI-06-0141. PMID 16896035. 
  • Gallagher CJ, Muscat JE, Hicks AN, et al. (2007). "The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer.". Cancer Epidemiol. Biomarkers Prev. 16 (4): 823–8. doi:10.1158/1055-9965.EPI-06-0823. PMID 17416778. 
  • Park JY, Tanner JP, Sellers TA, et al. (2007). "Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk.". Urology 70 (2): 374–9. doi:10.1016/j.urology.2007.03.001. PMID 17826523. 
  • Chouinard S, Barbier O, Bélanger A (2008). "UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells.". J. Biol. Chem. 282 (46): 33466–74. doi:10.1074/jbc.M703370200. PMID 17848572.