UGT1A9

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UDP glucuronosyltransferase 1 family, polypeptide A9
Identifiers
Symbols UGT1A9 ; HLUGP4; LUGP4; UDPGT; UDPGT 1-9; UGT-1I; UGT1-09; UGT1-9; UGT1.9; UGT1AI; UGT1I
External IDs OMIM606434 MGI3576092 HomoloGene133281 ChEMBL: 1743319 GeneCards: UGT1A9 Gene
EC number 2.4.1.17
Orthologs
Species Human Mouse
Entrez 54600 394430
Ensembl ENSG00000241119 ENSMUSG00000090165
UniProt O60656 D3Z7G0
RefSeq (mRNA) NM_021027 NM_201641
RefSeq (protein) NP_066307 NP_964003
Location (UCSC) Chr 2:
234.58 – 234.68 Mb
Chr 1:
88.06 – 88.22 Mb
PubMed search [1] [2]

UDP-glucuronosyltransferase 1-9 is an enzyme that in humans is encoded by the UGT1A9 gene.[1][2][3][4]

Function[edit]

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.[4]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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IrinotecanPathway_WP46359 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article
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  1. ^ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP46359". 

References[edit]

  1. ^ Wooster R, Sutherland L, Ebner T, Clarke D, Da Cruz e Silva O, Burchell B (September 1991). "Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family". Biochem. J. 278 (2): 465–9. PMC 1151367. PMID 1910331. 
  2. ^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (Oct 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054. 
  3. ^ Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (Mar 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J Biol Chem 267 (5): 3257–61. PMID 1339448. 
  4. ^ a b "Entrez Gene: UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.