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ALG3, alpha-1,3- mannosyltransferase
Symbols ALG3 ; CDG1D; CDGS4; D16Ertd36e; NOT56L; Not56
External IDs OMIM608750 MGI1098592 HomoloGene4228 GeneCards: ALG3 Gene
EC number
Species Human Mouse
Entrez 10195 208624
Ensembl ENSG00000214160 ENSMUSG00000033809
UniProt Q92685 Q8K2A8
RefSeq (mRNA) NM_001006940 NM_145939
RefSeq (protein) NP_001006942 NP_666051
Location (UCSC) Chr 3:
183.96 – 183.97 Mb
Chr 16:
20.61 – 20.61 Mb
PubMed search [1] [2]

Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase is an enzyme that in humans is encoded by the ALG3 gene.[1][2]

This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation.[2]


  1. ^ Jerrold LE (Dec 1975). "Will an electric current replace the syringe for anesthesia?". Dent Stud 53 (5): 49, 54. PMID 1058125. 
  2. ^ a b "Entrez Gene: ALG3 asparagine-linked glycosylation 3 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)". 

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