Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase is an enzyme that in humans is encoded by the ALG3gene.
This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation.
Denecke J, Kranz C, Kemming D et al. (2004). "An activated 5' cryptic splice site in the human ALG3 gene generates a premature termination codon insensitive to nonsense-mediated mRNA decay in a new case of congenital disorder of glycosylation type Id (CDG-Id).". Hum. Mutat.23 (5): 477–86. doi:10.1002/humu.20026. PMID15108280.CS1 maint: Explicit use of et al. (link)
Denecke J, Kranz C, von Kleist-Retzow JCh et al. (2005). "Congenital disorder of glycosylation type Id: clinical phenotype, molecular analysis, prenatal diagnosis, and glycosylation of fetal proteins.". Pediatr. Res.58 (2): 248–53. doi:10.1203/01.PDR.0000169963.94378.B6. PMID16006436.CS1 maint: Explicit use of et al. (link)