UGT2B15

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UDP glucuronosyltransferase 2 family, polypeptide B15
Identifiers
Symbols UGT2B15 ; HLUG4; UDPGT 2B8; UDPGT2B15; UDPGTH3; UGT2B8
External IDs OMIM600069 MGI3576100 HomoloGene133957 ChEMBL: 6161 GeneCards: UGT2B15 Gene
EC number 2.4.1.17
Orthologs
Species Human Mouse
Entrez 7366 22238
Ensembl ENSG00000196620 ENSMUSG00000054630
UniProt P54855 D3YUP6
RefSeq (mRNA) NM_001076 NM_009467
RefSeq (protein) NP_001067 NP_033493
Location (UCSC) Chr 4:
69.51 – 69.54 Mb
Chr 5:
87.12 – 87.14 Mb
PubMed search [1] [2]

UDP-glucuronosyltransferase 2B15 is an enzyme that in humans is encoded by the UGT2B15 gene.[1][2]

The UGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B8 demonstrates reactivity with estriol. See UGT2B4 (MIM 600067).[supplied by OMIM][2]

References[edit]

  1. ^ Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B (Feb 1995). "Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13". Genomics 23 (2): 496–9. doi:10.1006/geno.1994.1531. PMID 7835904. 
  2. ^ a b "Entrez Gene: UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15". 

Further reading[edit]

  • Coffman BL, Tephly TR, Irshaid YM, et al. (1990). "Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase.". Arch. Biochem. Biophys. 281 (1): 170–5. doi:10.1016/0003-9861(90)90428-2. PMID 2116769. 
  • Irshaid YM, Tephly TR (1987). "Isolation and purification of two human liver UDP-glucuronosyltransferases.". Mol. Pharmacol. 31 (1): 27–34. PMID 3100939. 
  • Green MD, Clarke DJ, Oturu EM, et al. (1995). "Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols.". Arch. Biochem. Biophys. 322 (2): 460–8. doi:10.1006/abbi.1995.1489. PMID 7574722. 
  • Green MD, Oturu EM, Tephly TR (1995). "Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates.". Drug Metab. Dispos. 22 (5): 799–805. PMID 7835232. 
  • Chen F, Ritter JK, Wang MG, et al. (1993). "Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms.". Biochemistry 32 (40): 10648–57. doi:10.1021/bi00091a015. PMID 8399210. 
  • Guillemette C, Lévesque E, Beaulieu M, et al. (1997). "Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells.". Endocrinology 138 (7): 2998–3005. doi:10.1210/en.138.7.2998. PMID 9202245. 
  • Lévesque E, Beaulieu M, Green MD, et al. (1997). "Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene.". Pharmacogenetics 7 (4): 317–25. doi:10.1097/00008571-199708000-00007. PMID 9295060. 
  • Strassburg CP, Strassburg A, Nguyen N, et al. (1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus.". Biochem. J. 338 (2): 489–98. doi:10.1042/0264-6021:3380489. PMC 1220077. PMID 10024527. 
  • Tchernof A, Lévesque E, Beaulieu M, et al. (1999). "Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method.". Clin. Endocrinol. (Oxf) 50 (5): 637–42. doi:10.1046/j.1365-2265.1999.00709.x. PMID 10468930. 
  • Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.". J. Biol. Chem. 275 (46): 36164–71. doi:10.1074/jbc.M002180200. PMID 10748067. 
  • Gsur A, Preyer M, Haidinger G, et al. (2002). "A polymorphism in the UDP-Glucuronosyltransferase 2B15 gene (D85Y) is not associated with prostate cancer risk.". Cancer Epidemiol. Biomarkers Prev. 11 (5): 497–8. PMID 12010866. 
  • Iida A, Saito S, Sekine A, et al. (2002). "Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8.". J. Hum. Genet. 47 (10): 505–10. doi:10.1007/s100380200075. PMID 12376738. 
  • Court MH, Duan SX, Guillemette C, et al. (2003). "Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9.". Drug Metab. Dispos. 30 (11): 1257–65. doi:10.1124/dmd.30.11.1257. PMID 12386133. 
  • Kanaya J, Takashima M, Koh E, Namiki M (2003). "Androgen-independent growth in LNCaP cell lines and steroid uridine diphosphate-glucuronosyltransferase expression.". Asian J. Androl. 5 (1): 9–13. PMID 12646996. 
  • Zhang JY, Zhan J, Cook CS, et al. (2003). "Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism.". Drug Metab. Dispos. 31 (5): 652–8. doi:10.1124/dmd.31.5.652. PMID 12695355. 
  • Tomboc M, Witchel SF (2003). "Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism.". J. Pediatr. Endocrinol. Metab. 16 (5): 719–26. doi:10.1515/jpem.2003.16.5.719. PMID 12880121. 
  • Court MH, Hao Q, Krishnaswamy S, et al. (2005). "UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver.". J. Pharmacol. Exp. Ther. 310 (2): 656–65. doi:10.1124/jpet.104.067660. PMID 15044558. 
  • Toide K, Umeda S, Yamazaki H, et al. (2005). "A major genotype in UDP-glucuronosyltransferase 2B15.". Drug Metab. Pharmacokinet. 17 (2): 164–6. doi:10.2133/dmpk.17.164. PMID 15618667. 
  • Chouinard S, Pelletier G, Bélanger A, Barbier O (2005). "Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium.". Endocr. Res. 30 (4): 717–25. doi:10.1081/ERC-200044014. PMID 15666817.