UGT1A8

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UDP glucuronosyltransferase 1 family, polypeptide A8
Identifiers
Symbols UGT1A8 ; UDPGT; UDPGT 1-8; UGT-1H; UGT1-08; UGT1.8; UGT1A8S; UGT1H
External IDs OMIM606433 MGI3576090 HomoloGene133281 ChEMBL: 1743318 GeneCards: UGT1A8 Gene
EC number 2.4.1.17
Orthologs
Species Human Mouse
Entrez 54576 394430
Ensembl ENSG00000242366 ENSMUSG00000090165
UniProt Q9HAW9 D3Z7G0
RefSeq (mRNA) NM_019076 NM_201641
RefSeq (protein) NP_061949 NP_964003
Location (UCSC) Chr 2:
234.53 – 234.68 Mb
Chr 1:
88.06 – 88.22 Mb
PubMed search [1] [2]

UDP-glucuronosyltransferase 1-8 is an enzyme that in humans is encoded by the UGT1A8 gene.[1][2][3]

Function[edit]

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.[1]

References[edit]

  1. ^ a b Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (Mar 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J Biol Chem 267 (5): 3257–61. PMID 1339448. 
  2. ^ Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH (June 2002). "Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3". Pharmacogenetics 12 (4): 287–97. doi:10.1097/00008571-200206000-00004. PMID 12042666. 
  3. ^ "Entrez Gene: UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8". 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.