WAY-213,613

WAY-213,613
Identifiers
	IUPAC name (2S)-2-amino-4-[4-(2-bromo-4,5-difluorophenoxy)anilino]-4-oxobutanoic acid;
CAS Number	868359-05-1;
PubChem CID	11531745;
ChEMBL	ChEMBL1628669;
CompTox Dashboard (EPA)	DTXSID60468142 ;
ECHA InfoCard	100.212.988
Chemical and physical data
Formula	C16H13BrF2N2O4
Molar mass	415.186 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=CC=C1NC(=O)C[C@@H](C(=O)O)N)OC2=CC(=C(C=C2Br)F)F;
	(verify)

WAY-213,613 is a drug which acts as a reuptake inhibitor for the glutamate transporter subtype EAAT₂, selective over other glutamate transporter subtypes and highly selective over metabotropic and ionotropic glutamate receptors.^[1] It is used in scientific research into the function of the glutamate transporters.^[2]

References

^ Dunlop, J; McIlvain, HB; Carrick, TA; Jow, B; Lu, Q; Kowal, D; Lin, S; Greenfield, A; Grosanu, C (2005). "Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2". Molecular Pharmacology. 68 (4): 974–82. doi:10.1124/mol.105.012005. PMID 16014807.
^ Karatas-Wulf, U; Koepsell, H; Bergert, M; Sönnekes, S; Kugler, P (2009). "Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells". Neuroscience. 161 (3): 794–805. doi:10.1016/j.neuroscience.2009.04.017. PMID 19364521.

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