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[[File:Caligrapefruit.jpg|thumb|120px|A grapefruit from southern California]]
[[File:Caligrapefruit.jpg|thumb|120px|A grapefruit from southern California]]
[[File:Grapefruit-mercaptan-2D-skeletal-vertical.png|left|80px|thumb|Grapefruit mercaptan]]
[[File:Grapefruit-mercaptan-2D-skeletal-vertical.png|left|80px|thumb|Grapefruit mercaptan]]
Grapefruit comes in many varieties, determinable by color, which is caused by the pigmentation of the fruit in respect of both its state of ripeness.<ref name="WHF"/> The most popular varieties cultivated today are [[red]], [[white]], and [[pink]] hues, referring to the internal pulp color of the fruit. The family of flavors range from highly acidic and somewhat sour to sweet and tart.<ref name="WHF"/> [[Grapefruit mercaptan]], a [[sulfur]]-containing [[terpene]], is one of the substances which has a strong influence on the taste and odor of grapefruit, compared with other citrus fruits.<ref name="Andrea_Buettner_and_Peter_Schieberle">{{cite journal
Grapefruit comes in many varieties, determinable by color, which is caused by the pigmentation of the fruit in respect of its state of ripeness.<ref name="WHF"/> The most popular varieties cultivated today are [[red]], [[white]], and [[pink]] hues, referring to the internal pulp color of the fruit. The family of flavors range from highly acidic and somewhat sour to sweet and tart.<ref name="WHF"/> [[Grapefruit mercaptan]], a [[sulfur]]-containing [[terpene]], is one of the substances which has a strong influence on the taste and odor of grapefruit, compared with other citrus fruits.<ref name="Andrea_Buettner_and_Peter_Schieberle">{{cite journal
| title = Characterization of the Most Odor-Active Volatiles in Fresh, Hand-Squeezed Juice of Grapefruit (''Citrus paradisi Macfayden'')
| title = Characterization of the Most Odor-Active Volatiles in Fresh, Hand-Squeezed Juice of Grapefruit (''Citrus paradisi Macfayden'')
| author = A. Buettner, P. Schieberle
| author = A. Buettner, P. Schieberle

Revision as of 02:17, 14 August 2013

This article is about the fruit. For other uses, see Grapefruit (disambiguation).

Grapefruit
Grapefruit, hybrid citrus.
Scientific classification
Kingdom:
Plantae
(unranked):
Angiosperms
(unranked):
Eudicots
(unranked):
Rosids
Order:
Sapindales
Family:
Rutaceae
Genus:
Citrus
Species:
C. × paradisi
Binomial name
Citrus × paradisi
Macfad.

The grapefruit (Citrus × paradisi) is a subtropical citrus tree known for its sour to semi-sweet fruit, an 18th-century hybrid first bred in Barbados.[1] When found, it was named the "forbidden fruit";[2] and it has also been misidentified with the pomelo or shaddock (C. maxima), one of the parents of this hybrid, the other being sweet orange (C. × sinensis).[3]

These evergreen trees usually grow to around 5–6 meters (16–20 ft) tall, although they can reach 13–15 meters (43–49 ft). The leaves are dark green, long (up to 150 mm, 6 inches) and thin. It produces 5 cm (2 in) white four-petaled flowers. The fruit is yellow-orange skinned and largely an oblate spheroid; it ranges in diameter from 10–15 cm. The flesh is segmented and acidic, varying in color depending on the cultivars, which include white, pink and red pulps of varying sweetness (generally, the redder varieties are sweeter). The 1929 US Ruby Red (of the Redblush variety) has the first grapefruit patent.[4]

History

1750 Engraving of The Forbidden Fruit Tree by Georg Dionysius Ehret

One ancestor of the grapefruit was the Jamaican sweet orange (Citrus sinensis), itself an ancient hybrid of Asian origin; the other was the Indonesian pomelo (C. maxima). One story of the fruit's origins is that a certain "Captain Shaddock"[5] brought pomelo seeds to Jamaica and bred the first fruit.[6] However, it probably originated as a naturally occurring hybrid.[1]

                         FORBIDDEN-FRUIT-TREE
The Trunk, Leaves, and Flowers of this Tree, very much resemble
those of the Orange-tree.
The Fruit, when ripe, is something longer and larger than the largest
Orange; and exceeds, in the Delicacy of its Taste, the Fruit of every
Tree in this or any of our neighbouring Islands.
It hath somewhat of the Taste of a Shaddock; but far exceeds that, as
well as the best Orange, in its delicious Taste and Flavour.

—Description from Hughes' 1750 Natural History of Barbados.

The hybrid fruit, then called "the forbidden fruit", was first documented in 1750 by a Welshman, Rev. Griffith Hughes, who described specimens from Barbados in The Natural History of Barbados.[7][8] Currently, the grapefruit is said to be one of the "Seven Wonders of Barbados."[9]

The grapefruit was brought to Florida by Count Odet Philippe in 1823 in what is now known as Safety Harbor. Further crosses have produced the tangelo (1905), the Minneola tangelo (1931), and the oroblanco (1984).

The grapefruit was known as the shaddock or shattuck until the 19th century. Its current name alludes to clusters of the fruit on the tree, which often appear similar to grapes.[10] Botanically, it was not distinguished from the pomelo until the 1830s, when it was given the name Citrus paradisi. Its true origins were not determined until the 1940s. This led to the official name being altered to Citrus × paradisi, the "×" identifying its hybrid origin.[11][12]

Kimball Chase Atwood

An early pioneer in the American citrus industry was Kimball Chase Atwood, a wealthy entrepreneur who founded the Atwood Grapefruit Co. in the late 19th century. The Atwood Grove became the largest grapefruit grove in the world, with a yearly output of 80,000 boxes of fruit.[13] It was there that pink grapefruit was first discovered in 1906.[14]

Ruby Red grapefruit

The 1929 Ruby Red patent was associated with real commercial success, which came after the discovery of a red grapefruit growing on a pink variety. Only with the introduction of the Ruby Red did the grapefruit transform into a real agricultural success. The Red grapefruit, starting with the Ruby Red, has even become a symbolic fruit of Texas, where white "inferior" grapefruit were eliminated and only red grapefruit were grown for decades[citation needed]. Using radiation to trigger mutations, new varieties were developed to retain the red tones which typically faded to pink,[15] the Rio Red variety is the current (2007) Texas grapefruit with registered trademarks Rio Star and Ruby-Sweet, also sometimes promoted as "Reddest" and "Texas Choice".

Star Ruby

The Star Ruby is the darkest of the red varieties. Developed from an irradiated Hudson grapefruit, it has found limited commercial success because it is more difficult to grow than other varieties.[16][17]

Varieties

The primary varieties of Florida grapefruit are Ruby Red, Pink, Thompson, Marsh and Duncan.[18]

Production

Grapefruit and pomelo output in 2005

The United States is the top producer of grapefruit and pomelo followed by China and South Africa.

Top ten grapefruit (inc. pomelos) producers — 2007
Country Production (metric tons) Footnote
 United States 1,580,000
 People's Republic of China 547,000 F
 South Africa 430,000 F
 Mexico 390,000 F
 Syria 290,000 F
 Israel 245,000 *
 Turkey 181,923
 India 178,000 F
 Argentina 176,000 F
 Cuba 175,000 F
 World 5060000 A
No symbol = official figure, P = official figure, F = FAO estimate, * = Unofficial/Semi-official/mirror data, C = Calculated figure A = Aggregate (may include official, semi-official or estimates);

Source: Food And Agricultural Organization of United Nations: Economic And Social Department: The Statistical Division

Colors and flavors

A grapefruit from southern California
Grapefruit mercaptan

Grapefruit comes in many varieties, determinable by color, which is caused by the pigmentation of the fruit in respect of its state of ripeness.[19] The most popular varieties cultivated today are red, white, and pink hues, referring to the internal pulp color of the fruit. The family of flavors range from highly acidic and somewhat sour to sweet and tart.[19] Grapefruit mercaptan, a sulfur-containing terpene, is one of the substances which has a strong influence on the taste and odor of grapefruit, compared with other citrus fruits.[20]

Drug interactions

Main article: Grapefruit drug interactions

Grapefruit can have a number of interactions with drugs,[21] often increasing the effective potency of compounds. Researchers have identified 85 drugs with which grapefruit is known to have an adverse reaction.[22] Grapefruit contains a number of polyphenolic compounds, including the flavanone naringin, alongside the two furanocoumarins bergamottin and dihydroxybergamottin. These inhibit the drug-metabolizing enzyme isoform CYP3A4 predominately in the small intestine, but at higher doses also inhibit hepatic CYP3A4.[23] It is via inhibition of this enzyme that grapefruit increases the effects of a variety of drugs by increasing their bioavailability.[24][25][26][27][28][29] In particular grapefruit and bitter oranges are known to interact with statins.

When drugs are taken orally, they enter the gut lumen to be absorbed in the small intestine and sometimes, in the stomach. In order for drugs to be absorbed, they must pass through the epithelial cells that line the lumen wall before they can enter the hepatic portal circulation to be distributed systemically in blood circulation. Drugs are metabolized by drug-specific metabolizing enzymes in the epithelial cells. Metabolizing enzymes transform these drugs into metabolites. The primary purpose for drug metabolism is to detoxify, inactivate, solubilize and eliminate these drugs.[30] As a result, the amount of the drug in its original form that reaches systemic circulation is reduced due to this first-pass metabolism.

Grapefruit juice contains furanocoumarins. Furanocoumarins irreversibly inhibit a cytochrome P450 metabolizing enzyme called CYP3A4, as stated above. CYP3A4 is a metabolizing enzyme for almost 50% of drugs, and is found in the liver and small intestinal epithelial cells.[31] As a result, many drugs are impacted by consumption of grapefruit juice. When the metabolizing enzyme is inhibited, less of the drug will be metabolized by it in the epithelial cells. A decrease in drug metabolism means more of the original form of the drug could pass unchanged to systemic blood circulation.[30] An unexpected high dose of the drug in the blood could lead to fatal drug toxicity.[31]

The furanocoumarins found in grapefruit juice are natural chemicals. Thus, they are present in all forms of the fruit including freshly squeezed juice, frozen concentrate, and whole fruit). All these forms of the grapefruit juice have the potential to limit the metabolizing activity of CYP3A4. One whole grapefruit, or a glass of 200mL of grapefruit juice can cause drug overdose toxicity.[2][32]

According to a review done by the Canadian Medical Association, there is an increase in the number of potential drugs that can interact with grapefruit juice. From 2008 to 2012, the percentage of drugs that interact with grapefruit juice and causes serious harmful effects (gastrointestinal bleeding, nephrotoxicity) has increased from 17 to 43 percent.[2][32]

Interestingly, it seems that the interaction between grapefruit juice and other medication depends on the drug, and not the class of the drug. Drugs that interact with grapefruit juice share 3 common features: they are taken orally, normally only a small amount enters systemic blood circulation, and they are metabolized by CYP3A4.[2]

Although there is an increase in the number of drugs that interact with grapefruit juice, there is a simple way to avoid the drug-food interaction and avoid the harm. Patients should leave a 4 hour gap between taking the medication and grapefruit juice.[31] For drugs recently sold on the market, drugs have information pages (monographs) that provide information on any potential interaction between a medication and grapefruit juice.[31] Because there is a growing number of medications that interact with grapefruit juice,[2] patients should consult a pharmacist or physician before planning to take grapefruit juice with their medications.

Grapefruit juice may be the first drug-interacting fruit juice documented, but apple and orange juices have been also implicated in interfering with etoposide, a chemotherapy drug, some beta blocker drugs used to treat high blood pressure, and cyclosporine, taken by transplant patients to prevent rejection of their new organs.[33] Some citrus-based carbonated beverages (e.g., “Sun Drop”) also contain enough grapefruit juice to cause drug interactions, particularly in patients taking cyclosporine.

Unlike other fruits, grapefruit contains a large amount of naringin, and it can take up to 72 hours before the effects of the naringin on the CYP3A4 enzyme are seen. This is particularly problematic due to the fact that only 4 oz of grapefruit contain enough naringin to inhibit the metabolism of substrates of CYP3A4.

Nutritional properties

Grapefruit, raw, white, all areas
Nutritional value per 100 g (3.5 oz)
Energy138 kJ (33 kcal)
8.41 g
Sugars7.31 g
Dietary fiber1.1 g
0.10 g
0.69 g
Vitamins and minerals
VitaminsQuantity
%DV†
Thiamine (B1)
3%
0.037 mg
Riboflavin (B2)
2%
0.020 mg
Niacin (B3)
2%
0.269 mg
Pantothenic acid (B5)
6%
0.283 mg
Vitamin B6
3%
0.043 mg
Folate (B9)
3%
10 μg
Choline
1%
7.7 mg
Vitamin C
37%
33.3 mg
Vitamin E
1%
0.13 mg
MineralsQuantity
%DV†
Calcium
1%
12 mg
Iron
0%
0.06 mg
Magnesium
2%
9 mg
Manganese
1%
0.013 mg
Phosphorus
1%
8 mg
Potassium
5%
148 mg
Zinc
1%
0.07 mg
Other constituentsQuantity
Water90.48 g
Link to USDA Database entry
†Percentages estimated using US recommendations for adults,[34] except for potassium, which is estimated based on expert recommendation from the National Academies.[35]

Grapefruit is an excellent source of many nutrients and phytochemicals that contribute to a healthy diet. Grapefruit is a good source of vitamin C,[19][36] contains the fiber pectin,[37] and the pink and red hues contain the beneficial antioxidant lycopene.[19][38] Studies have shown grapefruit helps lower cholesterol,[19][39] and there is evidence that the seeds have antioxidant properties.[40] Grapefruit forms a core part of the "grapefruit diet", the theory being that the fruit's low glycemic index is able to help the body's metabolism burn fat.[41]

Grapefruit seed extract (GSE) has been shown to have strong antimicrobial properties against fungi.[42] It is also believed to have antimicrobial properties for bacteria, however there are no known studies that demonstrate its efficacy. Additionally, although GSE is promoted as a highly effective plant-based preservative by some natural personal care manufacturers, studies have shown that the apparent antimicrobial activity associated with GSE preparations is merely due to contamination with synthetic preservatives.[43][44][45][46][47]

Since grapefruit juice is known to inhibit enzymes necessary for the clearance of some drugs and hormones, some have hypothesized that grapefruit juice may play an indirect role in the development of hormone-dependent cancers. A 2007 study found a correlation between eating a quarter of grapefruit daily and a 30% increase in risk for breast cancer in post-menopausal women. The study points to the inhibition of CYP3A4 enzyme by grapefruit, which metabolizes estrogen.[48] However, a 2008 study has shown that grapefruit consumption does not increase breast cancer risk and found a significant decrease in breast cancer risk with greater intake of grapefruit in women who never used hormone therapy.[49]

Grapefruit contains large quantities of a simple polyamine called spermidine, which may be related to aging. It is known to be necessary for cell growth and maturation, and as cells age their level of spermidine is known to fall. Scientists have shown that feeding spermidine to worms, fruit flies and yeast significantly prolongs their lifespan. In addition, adding spermidine to the diet of mice decreased molecular markers of aging, and when human immune cells were cultured in a medium containing spermidine, they also lived longer.[50]

Grapefruit sweets

In Costa Rica, especially in Atenas, grapefruit are often cooked to remove their sourness, rendering them as sweets; they are also stuffed with dulce de leche, resulting in a dessert called toronja rellena (stuffed grapefruit).

Other uses

Grapefruit has also been investigated in cancer medicine pharmacodynamics. Its inhibiting effect on the metabolism of some drugs may allow smaller doses to be used, which can help to reduce costs.[51]

See also

References

  1. ^ a b Carrington, Sean; Fraser, HenryC (2003). "Grapefruit". A~Z of Barbados Heritage. Macmillan Caribbean. pp. 90–91. ISBN 0-333-92068-6. One of many citrus species grown in Barbados. This fruit is believed to have originated in Barbados as a natural cross between sweet orange (C. sinesis) and Shaddock (C. grandis), both of which were introduced from Asia in the seventeenth century. The grapefruit first appeared as an illustration entitled 'The Forbidden Fruit Tree' in the Rev. Griffith Hughes' The Natural History of Barbados (1750). This accords with the scientific name which literally means 'citrus of paradise'. The fruit was obviously fairly common around that time since George Washington in his Barbados Journal (1750-1751) mentions 'the Forbidden Fruit' as one of the local fruit available at a dinner party he attended. The plant was later described in the 1837 Flora of Jamaica as the Barbados Grapefruit. The historical arguments and experimental work on leaf enzymes and oils from possible parents all support a Barbadian origin for the fruit. {{cite book}}: |access-date= requires |url= (help); Cite has empty unknown parameter: |month= (help)
  2. ^ a b c d e Dowling, Curtis F.; Morton, Julia Frances (1987). Fruits of warm climates. Miami, FL: J. F. Morton. ISBN 0-9610184-1-0. OCLC 16947184.{{cite book}}: CS1 maint: multiple names: authors list (link)
  3. ^ Li, Xiaomeng (2010). "The Origin of Cultivated Citrus as Inferred from Internal Transcribed Spacer and Chloroplast DNA Sequence and Amplified Fragment Length Polymorphism Fingerprints". Journal of the American Society for Horticultural Science. 135 (4): 341. Retrieved 27 February 2013. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  4. ^ Texas grapefruit history, TexaSweet. Retrieved 2 July 2008.
  5. ^ A possible identification with an actual Captain Chaddock who traded in the West Indies in the 17th century, was suggested by J. Kumamoto, R. W. Scora, H. W. Lawton and W. A. Clerx, "Mystery of the forbidden fruit: Historical epilogue on the origin of the grapefruit, Citrus paradisi (Rutaceae)", Economic Botany, 41.1 (January, 1987:97-107).
  6. ^ Grapefruit: a fruit with a bit of a complex in Art Culinaire (Winter, 2007)
  7. ^ World Wide Words: Questions & Answers; Grapefruit. Abstract
  8. ^ Admin. (2010). "Welchman Hall Gully, Barbados". Barbados National Trust. Retrieved 11 July 2010. The Development of the Gully - The Gully was once part of a plantation owned by a Welshman called General William Asygell Williams over 200 years ago. Hence the name "Welchman Hall" gully. It was this man who first developed the gully with exotic trees and an orchard. Interestingly, the grapefruit is originally from Barbados and is rumoured to have started in Welchman Hall Gully. {{cite web}}: Cite has empty unknown parameter: |separator= (help)
  9. ^ Barbados Seven Wonders: The Grapefruit Tree. Abstract
  10. ^ "How did the grapefruit get its name?" Library of Congress. Science Reference Service, Everyday Mysteries. Retrieved August 2, 2009.
  11. ^ Texas Citrus: Puzzling Beginnings. Article
  12. ^ University of Florida: IFAS Extension; The Grapefruit. Template:PDFlink
  13. ^ "Manatee County a big part of citrus history". HeraldTribune.com. 2004-08-16. Retrieved 2011-12-17.
  14. ^ "Article". Hort.purdue.edu. Retrieved 2011-12-17.
  15. ^ William J Broad (28 August 2007). "Useful Mutants, Bred With Radiation". New York Times.
  16. ^ Sauls, Julian W. (1998). "Home fruit Production-Grapefruit". Retrieved 2013-07-22.
  17. ^ Center for Visual Computing. "Star Ruby grapefruit". Retrieved 2013-07-22.
  18. ^ "Go Florida Grapefruit". Go Florida Grapefruit. Retrieved 2011-12-17.
  19. ^ a b c d e The World's Healthiest Foods; Grapefruit. The George Mateljan Foundation. Article
  20. ^ A. Buettner, P. Schieberle (1999). "Characterization of the Most Odor-Active Volatiles in Fresh, Hand-Squeezed Juice of Grapefruit (Citrus paradisi Macfayden)". J. Agric. Food Chem. 47 (12): 5189–5193. doi:10.1021/jf990071l. PMID 10606593.
  21. ^ Seden K. Dickinson L. Khoo S. Back D.. Grapefruit-drug interactions. [Review]. Drugs. 2010;70(18):2373-407. PMID 21142260.
  22. ^ Rabin, Roni Caryn (December 17, 2012). "Grapefruit Is a Culprit in More Drug Reactions". New York Times.
  23. ^ Veronese ML, Gillen LP, Burke JP, Dorval EP, Hauck WW, Pequignot E, Waldman SA, Greenberg HE. Exposure-dependent inhibition of intestinal and hepatic CYP3A4 in vivo by grapefruit juice. Journal of Clinical Pharmacology. 2003;43(8):831–9. doi:10.1177/0091270003256059. PMID 12953340.
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  29. ^ Bakalar, Nicholas (21 March 2006). "Experts Reveal the Secret Powers of Grapefruit Juice". New York Times.
  30. ^ a b Pandit Introduction to Pharmaceutical Sciences
  31. ^ a b c d Pirmohamed Drug-grapefruit juice interactions BMJ 2013;346:f1
  32. ^ a b Bailey, David G.; Dresser, George; Arnold, J. Malcolm O. (2012). "Grapefruit-medication interactions: Forbidden fruit or avoidable consequences?". Canadian Medical Association Journal (Canadian Medical Association). doi:10.1503/cmaj.120951
  33. ^ "Fruit juice 'could affect drugs'". BBC News. 20 August 2008. :]
  34. ^ United States Food and Drug Administration (2024). "Daily Value on the Nutrition and Supplement Facts Labels". FDA. Archived from the original on 2024-03-27. Retrieved 2024-03-28.
  35. ^ National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Food and Nutrition Board; Committee to Review the Dietary Reference Intakes for Sodium and Potassium (2019). Oria, Maria; Harrison, Meghan; Stallings, Virginia A. (eds.). Dietary Reference Intakes for Sodium and Potassium. The National Academies Collection: Reports funded by National Institutes of Health. Washington, DC: National Academies Press (US). ISBN 978-0-309-48834-1. PMID 30844154. Archived from the original on 2024-05-09. Retrieved 2024-06-21.
  36. ^ Fellers PJ, Nikdel S, Lee HS (1990). "Nutrient content and nutrition labeling of several processed Florida citrus juice products". J Am Diet Assoc. 90 (8): 1079–84. PMID 2380455. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  37. ^ Cerda JJ, Robbins FL, Burgin CW, Baumgartner TG, Rice RW (1988). "The effects of grapefruit pectin on patients at risk for coronary heart disease without altering diet or lifestyle". Clin Cardiol. 11 (9): 589–94. doi:10.1002/clc.4960110902. PMID 3229016. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  38. ^ Lee HS (2000). "Objective measurement of red grapefruit juice color". J. Agric. Food Chem. 48 (5): 1507–11. doi:10.1021/jf9907236. PMID 10820051. {{cite journal}}: Unknown parameter |month= ignored (help)
  39. ^ Platt R (2000). "Current concepts in optimum nutrition for cardiovascular disease". Prev Cardiol. 3 (2): 83–7. doi:10.1111/j.1520-037X.2000.80364.x. PMID 11834923.
  40. ^ Armando C, Maythe S, Beatriz NP (1997). "Antioxidant activity of grapefruit seed extract on vegetable oils". J Sci Food Agric. 77 (4): 463–7. doi:10.1002/(SICI)1097-0010(199808)77:4<463::AID-JSFA62>3.0.CO;2-1.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  41. ^ WMUR Ch. 9: New Hampshire news, weather, sports and entertainment. Researchers Put Grapefruit Diet To Test: Grapefruit Compound Lowers Cholesterol, Helps Regulate Insulin. June 11, 2003. Article
  42. ^ Ignacio, C. and Thai, D. (2005). "Comparative Analysis of Antifungal Activity of Natural Remedies Versus Miconazole Nitrate Salt Against Candida Albicans"
  43. ^ Sakamoto S, Sato K, Maitani T, Yamada T (1996). "[Analysis of components in natural food additive "grapefruit seed extract" by HPLC and LC/MS]". Eisei Shikenjo Hokoku (in Japanese) (114): 38–42. PMID 9037863.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  44. ^ von Woedtke T, Schlüter B, Pflegel P, Lindequist U, Jülich WD (1999). "Aspects of the antimicrobial efficacy of grapefruit seed extract and its relation to preservative substances contained". Pharmazie. 54 (6): 452–6. PMID 10399191. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  45. ^ Takeoka G, Dao L, Wong RY, Lundin R, Mahoney N (2001). "Identification of benzethonium chloride in commercial grapefruit seed extracts". J. Agric. Food Chem. 49 (7): 3316–20. doi:10.1021/jf010222w. PMID 11453769. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  46. ^ Takeoka GR, Dao LT, Wong RY, Harden LA (2005). "Identification of benzalkonium chloride in commercial grapefruit seed extracts". J. Agric. Food Chem. 53 (19): 7630–6. doi:10.1021/jf0514064. PMID 16159196. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  47. ^ Ganzera M, Aberham A, Stuppner H (2006). "Development and validation of an HPLC/UV/MS method for simultaneous determination of 18 preservatives in grapefruit seed extract". J. Agric. Food Chem. 54 (11): 3768–72. doi:10.1021/jf060543d. PMID 16719494. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  48. ^ Monroe KR, Murphy SP, Kolonel LN, Pike MC (2007). "Prospective study of grapefruit intake and risk of breast cancer in postmenopausal women: the Multiethnic Cohort Study". Br. J. Cancer. 97 (3): 440–5. doi:10.1038/sj.bjc.6603880. PMC 2360312. PMID 17622247. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  49. ^ Kim EH, Hankinson SE, Eliassen AH, Willett WC (2008). "A prospective study of grapefruit and grapefruit juice intake and breast cancer risk" (PDF). Br. J. Cancer. 98 (1): 240–1. doi:10.1038/sj.bjc.6604105. PMC 2359690. PMID 18026192. Retrieved 26 June 2009. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  50. ^ "rsc.org".
  51. ^ Gandey A (18 July 2007). "Cut Cancer Drug Costs By Exploring Food Interactions". Medscape Medical News.

"Why Texas Grapefruit Is Important for Your Health", source: Pittman Davis, 2009

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