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Bis(5'-adenosyl)-triphosphatase

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bis(5'-adenosyl)-triphosphatase
Identifiers
EC no.3.6.1.29
CAS no.63951-94-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) is an enzyme that catalyzes the chemical reaction

P1,P3-bis(5'-adenosyl) triphosphate + H2O ADP + AMP

Thus, the two substrates of this enzyme are P1,P3-bis(5'-adenosyl) triphosphate and H2O, whereas its two products are ADP and AMP.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase. Other names in common use include dinucleosidetriphosphatase, diadenosine 5,5-P1,P3-triphosphatase, and 1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase. This enzyme participates metabolic pathways involved in purine metabolism, and may have a role in the development of small cell lung cancer, and non-small cell lung cancer.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1FHI, 2FHI, 4FIT, 5FIT, and 6FIT.

References

  • Jakubowski H, Guranowski A (1983). "Enzymes hydrolyzing ApppA and/or AppppA in higher plants Purification and some properties of diadenosine triphosphatase, diadenosine tetraphosphatase, and phosphodiesterase from yellow lupin (Lupinus luteus) seeds". J. Biol. Chem. 258 (16): 9982–9. PMID 6309793.
  • A; Villalba, R; Moreno, A; Quintanilla, M; Lobatón, CD; Sillero, A (1977). "Dinucleosidetriphosphatase from rat liver. Purification and properties". Eur. J. Biochem. 76 (2): 331–7. doi:10.1111/j.1432-1033.1977.tb11600.x. PMID 196848.