ATP2B1

ATP2B1
Identifiers
Aliases	ATP2B1, ATPase, Ca++ transporting, plasma membrane 1, PMCA1, PMCA1kb, ATPase plasma membrane Ca2+ transporting 1
External IDs	OMIM: 108731; MGI: 104653; HomoloGene: 55597; GeneCards: ATP2B1; OMA:ATP2B1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	89,709,300 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	98,862,005 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; Brodmann area 23; ; lateral nuclear group of thalamus; ; occipital lobe; ; primary visual cortex; ; jejunal mucosa; ; external globus pallidus; ; secondary oocyte; ; cartilage tissue; ; superior frontal gyrus;
	Top expressed in
	otolith organ; ; utricle; ; dorsal striatum; ; Region I of hippocampus proper; ; dentate gyrus of hippocampal formation granule cell; ; lateral geniculate nucleus; ; superior frontal gyrus; ; nucleus accumbens; ; medial geniculate nucleus; ; primary visual cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; PDZ domain binding; metal ion binding; calmodulin binding; protein binding; hydrolase activity; ATP binding; P-type calcium transporter activity; calcium ion transmembrane transporter activity; P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration; ATPase activity;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle; plasma membrane; apical part of cell; integral component of plasma membrane; dendrite membrane; neuronal cell body membrane; basolateral plasma membrane; apical plasma membrane; dendritic spine membrane; membrane raft; cytoplasmic side of plasma membrane; extracellular exosome; nucleus; glutamatergic synapse; GABA-ergic synapse; integral component of presynaptic active zone membrane; immunological synapse; cell junction; synapse;
Biological process	regulation of cardiac conduction; human ageing; cellular calcium ion homeostasis; cellular response to vitamin D; ion transport; ion transmembrane transport; brain development; calcium ion transmembrane transport; cellular response to corticosterone stimulus; transport; response to cold; calcium ion export; neural retina development; calcium ion transport; regulation of cytosolic calcium ion concentration; regulation of presynaptic cytosolic calcium ion concentration; calcium ion export across plasma membrane; negative regulation of cytokine production; regulation of vascular associated smooth muscle contraction; regulation of blood pressure; positive regulation of bone mineralization; negative regulation of cytosolic calcium ion concentration; positive regulation of calcium ion transport; regulation of cellular response to insulin stimulus;
	Sources:Amigo / QuickGO
Orthologs
	490
	67972
	ENSG00000070961
	ENSMUSG00000019943
	P20020
	G5E829
	NM_001001323; NM_001682
	NM_026482; NM_001359506; NM_001359507; NM_001359508; NM_001359509
NP_001001323; NP_001673; NP_001353449; NP_001353450; NP_001353451;
	NP_001353452; NP_001353453; NP_001353454; NP_001353455; NP_001353456; NP_001353457; NP_001353458; NP_001353459; NP_001353460; NP_001353461
	NP_080758; NP_001346435; NP_001346436; NP_001346437; NP_001346438
	Wikidata
View/Edit Human	View/Edit Mouse

Plasma membrane calcium-transporting ATPase 1 is an enzyme that in humans is encoded by the ATP2B1 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000070961 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019943 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Olson S, Wang MG, Carafoli E, Strehler EE, McBride OW (Jul 1991). "Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23". Genomics. 9 (4): 629–41. doi:10.1016/0888-7543(91)90356-J. PMID 1674727.
^ "Entrez Gene: ATP2B1 ATPase, Ca++ transporting, plasma membrane 1".

References

Further reading