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For the Three-Letter Abbreviation, see EEE (disambiguation).
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E3, E.III, E03, E-3 or E3 may refer to:
Biology and Medicine
- E3 Ubiquitin ligase, a protein component of proteasome-mediated protein degradation
- Dihydrolipoamide dehydrogenase, the third element of the pyruvate dehydrogenase complex
- E03, in ICD-10 code, other hypothyroidism
- Boeing E-3 Sentry, an AWACS aircraft based on the Boeing 707
- Fokker E.III, a 1915 Dutch fighter aircraft
- HMS E3, an E-class submarine of the British Royal Navy
- Pfalz E.III, a German aircraft
- Siemens-Schuckert E.III, a German aircraft
- E-3 (rank), a paygrade in the United States military
- EU three, Germany, United Kingdom and France, the three nations with the largest populations and economies within the European Union
- E3 Media, a creative digital agency based in the United Kingdom
- Economics for Equity and the Environment Network, a nonprofit organization based in Portland, Oregon, U.S.
- e3 Filing, a Regulatory Filing department within Computershare
- Electronic Entertainment Expo, an annual trade fair for the video game industry
- E3, a postcode district in the E postcode area for east London
Science and technology
- The Olympus E-3 DSLR, a flagship Olympus camera released in 2007.
- E-3 process, an obsolete development process associated with photographic transparency film
- Honda E3, a 1991 Honda E series ASIMO predecessor robot
- Olympus E-3, a digital SLR camera
- E3, a communications channel defined in the E-carrier standard
- E3 binding protein, a metabolic protein
- E03 expressway (Sri Lanka), Colombo–Katunayake Expressway in Sri Lanka
- E3 National Highway, one of the National Highways of Pakistan
- Second Link Expressway, route E3 in Johor, Malaysia
- E3 Series Shinkansen, a Japanese high-speed train
- EMC E3, a diesel locomotive
- European route E03, a European route
- LB&SCR E3 class, an 1894 British class of steam locomotives
- London Buses route E3, a bus route in London
- Mazda E engine#E3, an evolution of Mazda's xC design
- BMW E3, a German automobile
- E-3 visa, a non-immigrant visa allowing Australian citizens to live and work in the United States
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