Iron-chelate-transporting ATPase
| iron-chelate-transporting ATPase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.6.3.34 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, an iron-chelate-transporting ATPase (EC 3.6.3.34) is an enzyme that catalyzes the chemical reaction
- ATP + H2O + iron chelateout ADP + phosphate + iron chelatein
The 3 substrates of this enzyme are ATP, H2O, and iron chelate, whereas its 3 products are ADP, phosphate, and iron chelate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (iron-chelate-importing). This enzyme participates in abc transporters - general.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1L2P, 1L6T, and 2IHY.
References
- Shea CM, McIntosh MA (1991). "Nucleotide sequence and genetic organization of the ferric enterobactin transport system: homology to other periplasmic binding protein-dependent systems in Escherichia coli". Mol. Microbiol. 5 (6): 1415–28. doi:10.1111/j.1365-2958.1991.tb00788.x. PMID 1838574.
- Koster W, Bohm B (1992). "Point mutations in two conserved glycine residues within the integral membrane protein FhuB affect iron(III) hydroxamate transport". Mol. Gen. Genet. 232 (3): 399–407. doi:10.1007/bf00266243. PMID 1588908.
- Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr (1995). "Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases". Res. Microbiol. 146 (4): 271–8. doi:10.1016/0923-2508(96)81050-3. PMID 7569321.
- Saier MH Jr (1998). "Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya". Adv. Microb. Physiol. 40: 81–136. doi:10.1016/S0065-2911(08)60130-7. PMID 9889977.
- Mademidis A, Koster W (1998). "Transport activity of FhuA, FhuC, FhuD, and FhuB derivatives in a system free of polar effects, and stoichiometry of components involved in ferrichrome uptake". Mol. Gen. Genet. 258 (1–2): 156–65. doi:10.1007/s004380050718. PMID 9613584.