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Methylprednisolone

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Methylprednisolone
Clinical data
Trade namesMedrol, Meprolone, others
Other names(6α, 11β)-11,17,21-trihydroxy-6-methyl-pregna-1,4-diene-3,20-dione
AHFS/Drugs.comMonograph
MedlinePlusa682795
License data
Pregnancy
category
  • AU: A
Routes of
administration		IV, IM, by mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding78%
Metabolismliver primarily, kidney, tissues; CYP450: 3A4 substrate
Elimination half-lifeurine; Half-life: 18-26h (biological)
Identifiers
  • (1S,2R,8S,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.001.343 Edit this at Wikidata
Chemical and physical data
FormulaC22H30O5
Molar mass374.471 g/mol g·mol−1
3D model (JSmol)
  • O=C\1\C=C/[C@]4(/C(=C/1)[C@@H](C)C[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@](O)(C(=O)CO)CC[C@@H]23)C)C
  • InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1 checkY
  • Key:VHRSUDSXCMQTMA-PJHHCJLFSA-N checkY
  (verify)

Methylprednisolone, sold under the brand names Depo-Medrol and Solu-Medrol among others, is a corticosteroid medication used to suppress the immune system and decrease inflammation.[1] Conditions in which it is used include skin diseases, rheumatic disorders, allergies, asthma, croup, COPD, certain cancers, multiple sclerosis, and as add-on therapy for tuberculosis.[1] It is given by mouth or by injection into a vein or muscle.[1]

Serious side effects may include mental health problems and an increased risk of infection.[1] Common side effects with long-term use include osteoporosis, cataracts, weakness, easy bruising, and yeast infections.[1] For pregnant women, short-term use around the time of delivery is safe for the baby; however, long-term use during pregnancy may result in harm.[2] Methylprednisolone is in the glucocorticoid family of medication.[1]

Methylprednisolone was approved for medical use in 1955.[3] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[4] Methylprednisolone is available as a generic medication.[1] The wholesale cost in the developing world is about 3.81 to 9.35 USD per 500 mg vial.[5] In the United States a course of treatment typically costs less than 25 USD.[6]

Medical uses

Some 4-mg methylprednisolone tablets by Sandoz
Depo-Medrol (methylprednisolone acetate) injectable suspension

Like most adrenocortical steroids, methylprednisolone is typically used for its anti-inflammatory effects. However, glucocorticoids have a wide range of effects, including changes to metabolism and immune responses. The list of medical conditions for which methylprednisolone is prescribed is rather long, and is similar to other corticosteroids such as prednisolone. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. It is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notably systemic lupus erythematosus. It is also used as a treatment for multiple sclerosis.

Another potential use of methylprednisolone is for vestibular neuritis.[7]

After egg retrieval for a cycle of in vitro fertilization, methylprednisolone may be prescribed to prevent the body from rejecting the embryos being transferred, up to the time of implantation.[8][9]

Side effects

Long-term use of methylprednisolone, as with all corticosteroids, can be associated with hyperglycemia, decreased resistance to infection, swelling of face, weight gain, congestive cardiac insufficiency, fluid and sodium retention, edema, hypertension, increased eye pressure, glaucoma, osteoporosis, and psychosis, especially when used at high doses.[10][11] The most serious side effect occurs after the adrenal glands cease natural production of cortisol, which methylprednisolone will replace. Abrupt cessation of the drug after this occurs can result in a condition known as Addisonian crisis, which can be fatal. To prevent this, the drug is usually prescribed with a tapering dose, including a predosed "dose pack" detailing a specific number of tablets to take at designated times over a several-day period. Pharmacists sometimes advise that this drug may cause sleeplessness and "down" moods.

Measles and chicken pox are very dangerous and potentially fatal for people on methylprednisolone therapy. Exposure to these infections is especially risky for people who are not immune to them. Exposures like these should be reported to a physician immediately, and may be treated with prophylactic immunoglobulin. Also, live, attenuated vaccines can be bad for people taking immunosuppressive doses of methylprednisolone. The exception to this rule is patients receiving complete corticosteroid replacement therapy, e.g., for Addison's disease, who may follow standard immunization protocols.

Mechanism of action

Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The anti-inflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

See also

References

  1. ^ a b c d e f g "Methylprednisolone". The American Society of Health-System Pharmacists. Archived from the original on 27 November 2016. Retrieved 8 December 2016. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  2. ^ "Methylprednisolone Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 22 December 2016. Retrieved 22 December 2016. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  3. ^ Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 486. ISBN 9783527607495. Archived from the original on 2016-12-22. {{cite book}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  4. ^ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived from the original (PDF) on 13 December 2016. Retrieved 8 December 2016. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  5. ^ "Methylprednisolone". International Drug Price Indicator Guide. Retrieved 8 December 2016.
  6. ^ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 202. ISBN 9781284057560.
  7. ^ Strupp M, Zingler VC, Arbusow V, Niklas D, Maag KP, Dieterich M, Bense S, Theil D, Jahn K, Brandt T (July 2004). "Methylprednisolone, valacyclovir, or the combination for vestibular neuritis". N. Engl. J. Med. 351 (4): 354–61. doi:10.1056/NEJMoa033280. PMID 15269315. Archived from the original (PDF) on 2013-06-24. {{cite journal}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  8. ^ "Medications Commonly Used During the IVF Cycle". Continuum Reproductive Center. Archived from the original on 6 September 2013. Retrieved 14 June 2013. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  9. ^ "In Vitro Fertilization (IVF)". Reproductive Medicine Associates of Michigan. Archived from the original on 15 May 2013. Retrieved 14 June 2013. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  10. ^ "SOLU-MEDROL (methylprednisolone sodium succinate) injection, powder, for solution". National Institutes of Health. Retrieved 24 August 2012.
  11. ^ "Medrol (Methylprednisolone - Tablets by Pfizer)". Sfatul Medicului. Archived from the original on 5 April 2013. Retrieved 14 April 2013. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
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