RHOB

RHOB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FV8
Identifiers
Aliases	RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6, ras homolog family member B
External IDs	OMIM: 165370; MGI: 107949; HomoloGene: 68377; GeneCards: RHOB; OMA:RHOB - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	20,449,440 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	8,550,009 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; saphenous vein; ; popliteal artery; ; tibial arteries; ; vena cava; ; urethra; ; internal globus pallidus; ; nipple; ; left uterine tube; ; tail of epididymis;
	Top expressed in
	molar; ; decidua; ; granulocyte; ; dorsomedial hypothalamic nucleus; ; left lung lobe; ; olfactory tubercle; ; globus pallidus; ; lateral geniculate nucleus; ; stroma of bone marrow; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GDP binding; GTP binding; protein binding; GTPase activity; protein kinase binding;
Cellular component	cytosol; endosome; late endosome; membrane; late endosome membrane; focal adhesion; plasma membrane; early endosome; cleavage furrow; endosome membrane; extracellular exosome; nucleus; intracellular anatomical structure; cytoplasm; cell cortex; cell division site; intracellular membrane-bounded organelle;
Biological process	cell differentiation; regulation of cell migration; endosome to lysosome transport; endothelial tube morphogenesis; negative regulation of cell cycle; positive regulation of angiogenesis; positive regulation of endothelial cell migration; multicellular organism development; platelet activation; cell adhesion; negative regulation of cell migration; angiogenesis; Rho protein signal transduction; cellular response to ionizing radiation; protein transport; intracellular protein transport; regulation of small GTPase mediated signal transduction; cellular response to hydrogen peroxide; apoptotic process; small GTPase mediated signal transduction; positive regulation of apoptotic process; transport; mitotic cytokinesis; G protein-coupled receptor signaling pathway; actin filament organization; regulation of cell shape; cell migration; establishment or maintenance of actin cytoskeleton polarity; regulation of actin cytoskeleton organization; actin filament bundle assembly;
	Sources:Amigo / QuickGO
Orthologs
	388
	11852
	ENSG00000143878
	ENSMUSG00000054364
	P62745
	P62746
	NM_004040
	NM_007483
	NP_004031
	NP_031509
	Wikidata
View/Edit Human	View/Edit Mouse

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.^[5]^[6]

RHOB is a member of the Rho GTP-binding protein family.^[7]

Interactions

RHOB has been shown to interact with CIT,^[8] ARHGEF3,^[9] ARHGDIG^[10] and RHPN2.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143878 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054364 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RHOB ras homolog gene family, member B".
^ Chardin P, Madaule P, Tavitian A (March 1988). "Coding sequence of human rho cDNAs clone 6 and clone 9". Nucleic Acids Research. 16 (6): 2717. doi:10.1093/nar/16.6.2717. PMC 336400. PMID 3283705.
^ Wennerberg K, Der CJ (March 2004). "Rho-family GTPases: it's not only Rac and Rho (and I like it)". Journal of Cell Science. 117 (Pt 8): 1301–12. doi:10.1242/jcs.01118. PMID 15020670.
^ Madaule, P; Furuyashiki T; Reid T; Ishizaki T; Watanabe G; Morii N; Narumiya S (Dec 1995). "A novel partner for the GTP-bound forms of rho and rac". FEBS Lett. 377 (2). NETHERLANDS: 243–8. doi:10.1016/0014-5793(95)01351-2. ISSN 0014-5793. PMID 8543060. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Arthur, William T; Ellerbroek Shawn M; Der Channing J; Burridge Keith; Wennerberg Krister (Nov 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45). United States: 42964–72. doi:10.1074/jbc.M207401200. ISSN 0021-9258. PMID 12221096. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Zalcman, G; Closson V; Camonis J; Honoré N; Rousseau-Merck M F; Tavitian A; Olofsson B (Nov 1996). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. 271 (48). UNITED STATES: 30366–74. doi:10.1074/jbc.271.48.30366. ISSN 0021-9258. PMID 8939998. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Mircescu, Hortensia; Steuve Séverine; Savonet Valérie; Degraef Chantal; Mellor Harry; Dumont Jacques E; Maenhaut Carine; Pirson Isabelle (Dec 2002). "Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP". Eur. J. Biochem. 269 (24). Germany: 6241–9. doi:10.1046/j.1432-1033.2002.03343.x. ISSN 0014-2956. PMID 12473120. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

RHOB

Interactions

References

Further reading

See also