Toxiferine

Toxiferine
Identifiers
CAS Number	302-30-7;
PubChem CID	5281411;
ChemSpider	4444760;
UNII	9M7D9K3OJI;
ChEMBL	ChEMBL231047;
CompTox Dashboard (EPA)	DTXSID30897243 ;
Chemical and physical data
Formula	C40H46N4O2
Molar mass	614.82 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [H][C@@]12[C@@]3(CC[N+]2(C)C/C4=C/CO)[C@@]5([H])N(C6=C3C=CC=C6)/C=C7[C@]([C@@]8(CC[N+]9(C)C/%10)[C@]9([H])C[C@]\7([H])C%10=C/CO)([H])N(C%11=C8C=CC=C%11)/C=C5/[C@]4([H])C1;

Toxiferine (C-toxiferine I) is a curare toxin. It is a bisindole alkaloid derived from Strychnos toxifera and a nicotinic acetylcholine receptor antagonist.

It is a muscle relaxant that causes paralysis of skeletal muscle, which takes approximately 2 hours to recovery for a moderate dose, and 8 hours of total paralysis with a 20-fold paralytic dose.^[1]

References

^ Page 330 in: The Alkaloids: v. 1: A Review of Chemical Literature (Specialist Periodical Reports). Cambridge, Eng: Royal Society of Chemistry. 1971. ISBN 0-85186-257-8.

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[1] Page 330 in: The Alkaloids: v. 1: A Review of Chemical Literature (Specialist Periodical Reports). Cambridge, Eng: Royal Society of Chemistry. 1971. ISBN 0-85186-257-8.

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