Trimetozine

Trimetozine
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name Morpholin-4-yl-(3,4,5-trimethoxyphenyl)methanone;
CAS Number	635-41-6;
PubChem CID	12478;
ChemSpider	11968;
UNII	31EPT7G9PL;
ChEMBL	ChEMBL1697853;
CompTox Dashboard (EPA)	DTXSID8023713 ;
ECHA InfoCard	100.010.215
Chemical and physical data
Formula	C14H19NO5
Molar mass	281.304 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=CC(=CC(=C1OC)OC)C(=O)N2CCOCC2;

Trimetozine (Opalene, Trimolide, Trioxazine) is a sedative that has been marketed in Europe since 1959.^[1]^[2] It also has mild tranquilizing effects and has been used in the treatment of anxiety.^[3]^[4] Its mechanism of action is unclear.^{[citation needed]}

References

^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 1932. ISBN 3-88763-075-0.
^ David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9.
^ Taverna P, Ferrari G (June 1970). "[Clinical trial of a new tranquilizing agent: trioxazine]". Minerva Medica (in Italian). 61 (46): 2574–90. PMID 5425739.
^ Shpak VM, Shcheglova AIu (August 1968). "[Trioxazine in the treatment of night anxiety in children]". Pediatriia (in Russian). 47 (8): 76–7. PMID 5730033.

[isbn3-88763-075-0-1] Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 1932. ISBN 3-88763-075-0.

[isbn0-412-46630-9-2] David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9.

[pmid5425739-3] Taverna P, Ferrari G (June 1970). "[Clinical trial of a new tranquilizing agent: trioxazine]". Minerva Medica (in Italian). 61 (46): 2574–90. PMID 5425739.

[pmid5730033-4] Shpak VM, Shcheglova AIu (August 1968). "[Trioxazine in the treatment of night anxiety in children]". Pediatriia (in Russian). 47 (8): 76–7. PMID 5730033.

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[4]

v t e Anxiolytics (N05B)
5-HT_1ARTooltip 5-HT1A receptor agonists	Buspirone Gepirone Tandospirone
GABA_ARTooltip GABAA receptor PAMsTooltip positive allosteric modulators	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem^‡ Barbiturates (e.g., phenobarbital) Carbamates (e.g., meprobamate) Carisoprodol Chlormezanone^‡ Ethanol (alcohol) Etifoxine
Hypnotics	Zopiclone
Gabapentinoids (α₂δ VDCC blockers)	Gabapentin Gabapentin enacarbil Phenibut Pregabalin
Antidepressants	SSRIsTooltip Selective serotonin reuptake inhibitors (e.g., escitalopram) SNRIsTooltip Serotonin-norepinephrine reuptake inhibitors (e.g., duloxetine) SARIsTooltip Serotonin antagonist and reuptake inhibitors (e.g., trazodone) TCAsTooltip Tricyclic antidepressants (e.g., clomipramine^#) TeCAsTooltip Tetracyclic antidepressants (e.g., mirtazapine) MAOIsTooltip Monoamine oxidase inhibitors (e.g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine
Antipsychotics	Quetiapine Flupentixol
Sympatholytics (Antiadrenergics)	Alpha-1 blockers (e.g., prazosin) Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) Beta blockers (e.g., propranolol)
Others	Benzoctamine Cycloserine Fabomotizole Hydroxyzine Lorpiprazole Mebicar Mepiprazole Nicotine Opipramol Oxaflozane^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III