Fenmetozole: Difference between revisions
Content deleted Content added
←Created page with '{{Drugbox | IUPAC_name = 2-[(3,4-dichlorophenoxy)methyl]-4,5-dihydro-1''H''-imidazole | image = Fenmetozole.png | CAS_number ...' |
(No difference)
|
Revision as of 00:10, 20 September 2010
 | |
| Clinical data | |
|---|---|
| ATC code |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C10H10Cl2N2O |
| Molar mass | 245.11 g/mol g·mol−1 |
| 3D model (JSmol) | |
| |
Fenmetozole (DH-524) is a drug which was patented as an antidepressant, but was later studied as an antagonist of the effects of ethanol, though results were poor and it even increased its effects in some cases.[1][2][3][4][5] It acts as an α2-adrenergic receptor antagonist similarly to other imidazoles like idazoxan.[6]
References
- ^ McNamee HB, Mendelson JH, Korn J (1975). "Fenmetozole in acute alcholol intoxication in man". Clinical Pharmacology and Therapeutics. 17 (6): 735–7. PMID 1095283.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Griffis LC, Bright TP, Cerimele BJ, Forney RB (1978). "Combined effects of fenmetozole and ethanol". Clinical Pharmacology and Therapeutics. 24 (3): 350–3. PMID 357069.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Frye GD, Breese GR, Mailman RB, Vogel RA, Ondrusek MG, Mueller RA (1980). "An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function". Psychopharmacology. 69 (2): 149–55. PMID 6256788.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Vogel RA, Frye GD, Koepke KM, Mailman RB, Mueller RA, Breese GR (1981). "Differential effects of TRH, amphetamine, naloxone, and fenmetozole on ethanol actions: attenuation of the effects of punishment and impairment of aerial righting reflex". Alcoholism, Clinical and Experimental Research. 5 (3): 386–92. PMID 6792942.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Frye GD, Breese GR (1981). "An evaluation of the locomotor stimulating action of ethanol in rats and mice". Psychopharmacology. 75 (4): 372–9. PMID 6803283.
- ^ Stillings MR, England CD, Welbourn AP, Smith CF (1986). "Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists". Journal of Medicinal Chemistry. 29 (9): 1780–3. PMID 2875186.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)