Potassium canrenoate: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
No edit summary
No edit summary
Line 56: Line 56:
'''Potassium canrenoate''' ([[International Nonproprietary Name|INN]], [[Japanese Accepted Name|JAN]]) or '''canrenoate potassium''' ([[United States Adopted Name|USAN]]) (brand names '''Venactone''', '''Soldactone'''), also known as '''aldadiene kalium''',<ref name="Selye2013">{{cite book|author=Hans Selye|title=Hormones and Resistance: Part 1 and|url=https://books.google.com/books?id=NdvnCAAAQBAJ&pg=PA186|date=17 April 2013|publisher=Springer Science & Business Media|isbn=978-3-642-65192-2|pages=186–}}</ref> the [[potassium]] [[salt (chemistry)|salt]] of [[canrenoic acid]], is an [[aldosterone antagonist]] of the [[spirolactone]] group.<ref name="HillMakin1991">{{cite book|author1=R.A. Hill|author2=H.L.J. Makin|author3=D.N. Kirk|author4=G.M. Murphy|title=Dictionary of Steroids|url=https://books.google.com/books?id=qw5X0NK1A90C&pg=PA656|date=23 May 1991|publisher=CRC Press|isbn=978-0-412-27060-4|pages=656–}}</ref> Like [[spironolactone]], it is a [[prodrug]], which is [[drug metabolism|metabolized]] to [[canrenone]] in the body.{{Citation needed|date=May 2017}}
'''Potassium canrenoate''' ([[International Nonproprietary Name|INN]], [[Japanese Accepted Name|JAN]]) or '''canrenoate potassium''' ([[United States Adopted Name|USAN]]) (brand names '''Venactone''', '''Soldactone'''), also known as '''aldadiene kalium''',<ref name="Selye2013">{{cite book|author=Hans Selye|title=Hormones and Resistance: Part 1 and|url=https://books.google.com/books?id=NdvnCAAAQBAJ&pg=PA186|date=17 April 2013|publisher=Springer Science & Business Media|isbn=978-3-642-65192-2|pages=186–}}</ref> the [[potassium]] [[salt (chemistry)|salt]] of [[canrenoic acid]], is an [[aldosterone antagonist]] of the [[spirolactone]] group.<ref name="HillMakin1991">{{cite book|author1=R.A. Hill|author2=H.L.J. Makin|author3=D.N. Kirk|author4=G.M. Murphy|title=Dictionary of Steroids|url=https://books.google.com/books?id=qw5X0NK1A90C&pg=PA656|date=23 May 1991|publisher=CRC Press|isbn=978-0-412-27060-4|pages=656–}}</ref> Like [[spironolactone]], it is a [[prodrug]], which is [[drug metabolism|metabolized]] to [[canrenone]] in the body.{{Citation needed|date=May 2017}}


Potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for [[parenteral]] [[route of administration|administration]] as opposed to solely [[oral administration]].<ref name="pmid28634268">{{cite journal | vauthors = Kolkhof P, Bärfacker L | title = 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development | journal = J. Endocrinol. | volume = 234 | issue = 1 | pages = T125–T140 | year = 2017 | pmid = 28634268 | doi = 10.1530/JOE-16-0600 | url = }}</ref>
Potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for [[parenteral]] [[route of administration|administration]] (specifically [[intravenous]])<ref name="Bonjer2017">{{cite book|author=H. Jaap Bonjer|title=Surgical Principles of Minimally Invasive Procedures: Manual of the European Association of Endoscopic Surgery (EAES)|url=https://books.google.com/books?id=tAImDwAAQBAJ&pg=PA136|date=21 June 2017|publisher=Springer|isbn=978-3-319-43196-3|pages=136–}}</ref> as opposed to [[oral administration]].<ref name="pmid28634268">{{cite journal | vauthors = Kolkhof P, Bärfacker L | title = 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development | journal = J. Endocrinol. | volume = 234 | issue = 1 | pages = T125–T140 | year = 2017 | pmid = 28634268 | doi = 10.1530/JOE-16-0600 | url = }}</ref>


==See also==
==See also==

Revision as of 21:46, 4 July 2017

Potassium canrenoate
Clinical data
Other namesSC-14266
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Intravenous
ATC code
Pharmacokinetic data
MetabolismHepatic
ExcretionRenal and fecal
Identifiers
  • potassium 3-[(8R,9S,10R,13S,14S,17R)-
    17-hydroxy-10,13-dimethyl-3-oxo-2,8,9,
    11,12,14,15,16-octahydro-1H-cyclopenta[a]
    phenanthren-17-yl]propanoate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.016.868 Edit this at Wikidata
Chemical and physical data
FormulaC22H29KO4
Molar mass396.5616 g/mol g·mol−1
3D model (JSmol)
  • [K+].[O-]C(=O)CC[C@]3(O)CC[C@H]2[C@@H]4/C=C\C1=C\C(=O)CC[C@@]1([C@H]4CC[C@@]23C)C
  • InChI=1S/C22H30O4.K/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25);/q;+1/p-1/t16-,17+,18+,20+,21+,22-;/m1./s1 checkY
  • Key:JTZQCHFUGHIPDF-RYVBEKKQSA-M checkY
 ☒NcheckY (what is this?)  (verify)

Potassium canrenoate (INN, JAN) or canrenoate potassium (USAN) (brand names Venactone, Soldactone), also known as aldadiene kalium,[1] the potassium salt of canrenoic acid, is an aldosterone antagonist of the spirolactone group.[2] Like spironolactone, it is a prodrug, which is metabolized to canrenone in the body.[citation needed]

Potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for parenteral administration (specifically intravenous)[3] as opposed to oral administration.[4]

See also

References

  1. ^ Hans Selye (17 April 2013). Hormones and Resistance: Part 1 and. Springer Science & Business Media. pp. 186–. ISBN 978-3-642-65192-2.
  2. ^ R.A. Hill; H.L.J. Makin; D.N. Kirk; G.M. Murphy (23 May 1991). Dictionary of Steroids. CRC Press. pp. 656–. ISBN 978-0-412-27060-4.
  3. ^ H. Jaap Bonjer (21 June 2017). Surgical Principles of Minimally Invasive Procedures: Manual of the European Association of Endoscopic Surgery (EAES). Springer. pp. 136–. ISBN 978-3-319-43196-3.
  4. ^ Kolkhof P, Bärfacker L (2017). "30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development". J. Endocrinol. 234 (1): T125–T140. doi:10.1530/JOE-16-0600. PMID 28634268.
Stub icon

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Potassium_canrenoate&oldid=789026135"