EIF3A

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Eukaryotic translation initiation factor 3, subunit A
Identifiers
Symbols EIF3A ; EIF3; EIF3S10; P167; TIF32; eIF3-p170; eIF3-theta; p180; p185
External IDs OMIM602039 MGI95301 HomoloGene2779 GeneCards: EIF3A Gene
RNA expression pattern
PBB GE EIF3S10 200595 s at tn.png
PBB GE EIF3S10 200596 s at tn.png
PBB GE EIF3S10 200597 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8661 13669
Ensembl ENSG00000107581 ENSMUSG00000024991
UniProt Q14152 P23116
RefSeq (mRNA) NM_003750 NM_010123
RefSeq (protein) NP_003741 NP_034253
Location (UCSC) Chr 10:
120.79 – 120.84 Mb
Chr 19:
60.76 – 60.79 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 3 subunit A is a protein that in humans is encoded by the EIF3A gene.[1][2][3]


Interactions[edit]

EIF3A has been shown to interact with EIF3EIP,[4][5] EIF4B,[6] DISC1,[7] FBXO32,[8] EIF3D,[4][9][10] EIF3C,[9][10] EIF4G2,[11][12] EIF3B,[9][10][13][14] EIF3J,[9][10] EIF3S6,[4][5][9] EIF3F,[4][9][10] EIF3G,[9][10] EIF3H,[4][9][10] EIF3I[4][9][15] and EIF3K.[4][9]

References[edit]

  1. ^ Johnson KR, Merrick WC, Zoll WL, Zhu Y (April 1997). "Identification of cDNA clones for the large subunit of eukaryotic translation initiation factor 3. Comparison of homologues from human, Nicotiana tabacum, Caenorhabditis elegans, and Saccharomyces cerevisiae". J Biol Chem 272 (11): 7106–13. doi:10.1074/jbc.272.11.7106. PMID 9054404. 
  2. ^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (March 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280. 
  3. ^ "Entrez Gene: EIF3S10 eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa". 
  4. ^ a b c d e f g Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  5. ^ a b Morris-Desbois, C; Réty S; Ferro M; Garin J; Jalinot P (December 2001). "The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3". J. Biol. Chem. (United States) 276 (49): 45988–95. doi:10.1074/jbc.M104966200. ISSN 0021-9258. PMID 11590142. 
  6. ^ Méthot, N; Song M S; Sonenberg N (October 1996). "A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3". Mol. Cell. Biol. (UNITED STATES) 16 (10): 5328–34. ISSN 0270-7306. PMC 231531. PMID 8816444. 
  7. ^ Morris, Jill A; Kandpal Geeta; Ma Lei; Austin Christopher P (July 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. (England) 12 (13): 1591–608. doi:10.1093/hmg/ddg162. ISSN 0964-6906. PMID 12812986. 
  8. ^ Lagirand-Cantaloube, Julie; Offner Nicolas, Csibi Alfredo, Leibovitch Marie P, Batonnet-Pichon Sabrina, Tintignac Lionel A, Segura Carlos T, Leibovitch Serge A (April 2008). "The initiation factor eIF3-f is a major target for Atrogin1/MAFbx function in skeletal muscle atrophy". EMBO J. (England) 27 (8): 1266–76. doi:10.1038/emboj.2008.52. PMC 2367397. PMID 18354498. 
  9. ^ a b c d e f g h i j Mayeur, Greg L; Fraser Christopher S; Peiretti Franck; Block Karen L; Hershey John W B (October 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. (Germany) 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. ISSN 0014-2956. PMID 14519125. 
  10. ^ a b c d e f g Block, K L; Vornlocher H P; Hershey J W (November 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. (UNITED STATES) 273 (48): 31901–8. doi:10.1074/jbc.273.48.31901. ISSN 0021-9258. PMID 9822659. 
  11. ^ Gradi, A; Imataka H; Svitkin Y V; Rom E; Raught B; Morino S; Sonenberg N (January 1998). "A Novel Functional Human Eukaryotic Translation Initiation Factor 4G". Mol. Cell. Biol. (UNITED STATES) 18 (1): 334–42. ISSN 0270-7306. PMC 121501. PMID 9418880. 
  12. ^ Henis-Korenblit, S; Strumpf N L; Goldstaub D; Kimchi A (January 2000). "A Novel Form of DAP5 Protein Accumulates in Apoptotic Cells as a Result of Caspase Cleavage and Internal Ribosome Entry Site-Mediated Translation". Mol. Cell. Biol. (UNITED STATES) 20 (2): 496–506. doi:10.1128/MCB.20.2.496-506.2000. ISSN 0270-7306. PMC 85113. PMID 10611228. 
  13. ^ Harris, Thurl E; Chi An; Shabanowitz Jeffrey; Hunt Donald F; Rhoads Robert E; Lawrence John C (April 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO J. (England) 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047. ISSN 0261-4189. PMC 1440840. PMID 16541103. 
  14. ^ Méthot, N; Rom E; Olsen H; Sonenberg N (January 1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. (UNITED STATES) 272 (2): 1110–6. doi:10.1074/jbc.272.2.1110. ISSN 0021-9258. PMID 8995410. 
  15. ^ Asano, K; Kinzy T G; Merrick W C; Hershey J W (January 1997). "Conservation and diversity of eukaryotic translation initiation factor eIF3". J. Biol. Chem. (UNITED STATES) 272 (2): 1101–9. doi:10.1074/jbc.272.2.1101. ISSN 0021-9258. PMID 8995409. 

Further reading[edit]