MRPS30

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Mitochondrial ribosomal protein S30
Identifiers
Symbols MRPS30 ; MRP-S30; PAP; PDCD9; S30mt
External IDs OMIM611991 MGI1926237 HomoloGene9607 GeneCards: MRPS30 Gene
RNA expression pattern
PBB GE MRPS30 218398 at tn.png
PBB GE MRPS30 222275 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10884 59054
Ensembl ENSG00000112996 ENSMUSG00000021731
UniProt Q9NP92 Q9D0G0
RefSeq (mRNA) NM_016640 NM_021556
RefSeq (protein) NP_057724 NP_067531
Location (UCSC) Chr 5:
44.81 – 44.82 Mb
Chr 13:
118.38 – 118.39 Mb
PubMed search [1] [2]

28S ribosomal protein S30, mitochondrial is a protein that in humans is encoded by the MRPS30 gene.[1][2][3]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available.[3]

References[edit]

  1. ^ Carim L, Sumoy L, Nadal M, Estivill X, Escarceller M (May 2000). "Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52". Cytogenet Cell Genet 87 (1–2): 85–8. doi:10.1159/000015397. PMID 10640817. 
  2. ^ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123. 
  3. ^ a b "Entrez Gene: MRPS30 mitochondrial ribosomal protein S30". 

Further reading[edit]