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Eukaryotic translation initiation factor 3, subunit K
PBB Protein EIF3S12 image.jpg
PDB rendering based on 1rz4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EIF3K ; EIF3-p28; EIF3S12; HSPC029; M9; MSTP001; PLAC-24; PLAC24; PRO1474; PTD001
External IDs OMIM609596 MGI1921080 HomoloGene8292 GeneCards: EIF3K Gene
RNA expression pattern
PBB GE EIF3S12 212716 s at tn.png
PBB GE EIF3S12 221494 x at tn.png
PBB GE EIF3S12 210501 x at tn.png
More reference expression data
Species Human Mouse
Entrez 27335 73830
Ensembl ENSG00000178982 ENSMUSG00000053565
UniProt Q9UBQ5 Q9DBZ5
RefSeq (mRNA) NM_001300992 NM_001285942
RefSeq (protein) NP_001287921 NP_001272871
Location (UCSC) Chr 19:
39.11 – 39.13 Mb
Chr 7:
28.97 – 28.98 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 3 subunit K is a protein that in humans is encoded by the EIF3K gene.[1][2][3]


The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003).[supplied by OMIM][3]


EIF3K has been shown to interact with Cyclin D3[4] and EIF3A.[2][5]


  1. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ et al. (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. 
  2. ^ a b Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (Oct 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125. 
  3. ^ a b "Entrez Gene: EIF3S12 eukaryotic translation initiation factor 3, subunit 12". 
  4. ^ Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H et al. (Aug 2004). "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3". FEBS Lett. 573 (1-3): 139–46. doi:10.1016/j.febslet.2004.07.071. PMID 15327989. 
  5. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 

Further reading[edit]