Joseph Lister, 1st Baron Lister
|Joseph Lister, 1st Baron Lister|
5 April 1827|
|Died||10 February 1912
|Institutions||University of Glasgow
University of Edinburgh
University of London
|Alma mater||University of London|
|Known for||Surgical sterile techniques|
Joseph Lister, 1st Baron Lister, Bt., OM, FRS, PC (5 April 1827 – 10 February 1912), known as Sir Joseph Lister, Bt., between 1883 and 1897, was a British surgeon and a pioneer of antiseptic surgery. By applying Louis Pasteur's advances in microbiology, he promoted the idea of sterile surgery while working at the Glasgow Royal Infirmary. Lister successfully introduced carbolic acid (now known as phenol) to sterilise surgical instruments and to clean wounds, which led to a reduction in post-operative infections and made surgery safer for patients.
Early life and education 
At Quaker schools, he became a fluent reader of French and German, which were also the leading languages of medical research. As a teenager, Lister attended Grove House School Tottenham, studying mathematics, natural science, and languages.
He attended University College London, one of only a few institutions which accepted Quakers at that time. He initially studied botany and obtained a bachelor of Arts degree in 1847. He registered as a medical student and graduated with honours as Bachelor of Medicine, subsequently entering the Royal College of Surgeons at the age of 26. In 1854, Lister became both first assistant to and friend of surgeon James Syme at the University of Edinburgh, Edinburgh Royal Infirmary in Scotland.
In 1867, Lister championed the use of carbolic acid as an antiseptic, such that it became the first widely used antiseptic in surgery. He first suspected it would prove an adequate disinfectant because it was used to ease the stench from fields irrigated with sewage waste. He presumed it was safe because carbolic acid treated fields produced no apparent ill-effects on the livestock that later grazed upon them. He subsequently left the Quakers, joined the Scottish Episcopal Church, and eventually married Syme's daughter, Agnes. On their honeymoon, they spent 3 months visiting leading medical institutes (hospitals and universities) in France and Germany. By this time, Agnes was enamoured of medical research and was Lister's partner in the laboratory for the rest of her life.
Until Lister's studies of surgery most people believed that chemical damage from exposures to bad air (see "miasma") was responsible for infections in wounds. Hospital wards were occasionally aired out at midday as a precaution against the spread of infection via miasma, but facilities for washing hands or a patient's wounds were not available. A surgeon was not required to wash his hands before seeing a patient because such practices were not considered necessary to avoid infection. Despite the work of Ignaz Semmelweis and Dr. Oliver Wendell Holmes, Sr., hospitals practised surgery under unsanitary conditions. Surgeons of the time referred to the "good old surgical stink" and took pride in the accumulated stains on their unwashed operating gowns as a display of their experience. Lister’s house surgeon, St. Clair Thompson, recounted that Lister himself used to operate in his street clothes, wearing the same blue frock coat that he wore in the dissecting room, stiff with old blood.
While he was a professor of surgery at the University of Glasgow, Lister became aware of a paper published by the French chemist Louis Pasteur, showing that rotting and fermentation could occur under anaerobic conditions if micro-organisms were present. Pasteur suggested three methods to eliminate the micro-organisms responsible for gangrene: filtration, exposure to heat, or exposure to chemical solutions. Lister confirmed Pasteur's conclusions with his own experiments and decided to use his findings to develop antiseptic techniques for wounds. As the first two methods suggested by Pasteur were inappropriate for the treatment of human tissue, Lister experimented with the third.
Friedlieb Runge (1797–1867) discovered creosote, which later was processed into carbolic acid. Although Runge had no understanding of how decomposition occurred, the chemical had been used to treat the wood used for railway ties and ships since it protected the wood from rotting. Later, it was used for treating sewage in England, Belgium and Holland. The same chemical was also used to fight parasites and reduce the odors during cholera and cattle plague.
Therefore, Lister tested the results of spraying instruments, the surgical incisions, and dressings with a solution of it. Lister found that carbolic acid solution swabbed on wounds remarkably reduced the incidence of gangrene. In August 1865, Lister applied a piece of lint dipped in carbolic acid solution onto the wound of an eleven-year-old boy at Glasgow Infirmary, who had sustained a compound fracture after a cart wheel had passed over his leg. After four days, he renewed the pad and discovered that no infection had developed, and after a total of six weeks he was amazed to discover that the boy's bones had fused back together, without the danger of suppuration. He subsequently published his results in The Lancet in a series of 6 articles, running from March through July 1867, entitled: "On a new method of treating compound fracture, abscess, etc.: with observation on the conditions suppuration".  Later, on 9 August 1867, he read a paper before the British Medical Association in Dublin, on the Antiseptic Principle of the Practice of Surgery, which was reprinted in The British Medical Journal.
He instructed surgeons under his responsibility to wear clean gloves and wash their hands before and after operations with 5% carbolic acid solutions. Instruments were also washed in the same solution and assistants sprayed the solution in the operating theatre. One of his additional suggestions was to stop using porous natural materials in manufacturing the handles of medical instruments.
Lister left Glasgow in 1869, returning to Edinburgh as successor to Syme as Professor of Surgery at the University of Edinburgh, and continued to develop improved methods of antisepsis and asepsis. His fame had spread by then, and audiences of 400 often came to hear him lecture. As the germ theory of disease became more widely accepted, it was realised that infection could be better avoided by preventing bacteria from getting into wounds in the first place. This led to the rise of sterile surgery. Some consider Lister "the father of modern antisepsis".
Surgical technique 
Lister moved from Scotland to King's College Hospital, in London. In 1881 he was elected President of the Clinical Society of London. He also developed a method of repairing kneecaps with metal wire and improved the technique of mastectomy. His discoveries were greatly praised and in 1883 he was created a Baronet, of Park Crescent in the Parish of St Marylebone in the County of Middlesex. In 1897 he was further honoured when he was raised to the peerage as Baron Lister, of Lyme Regis in the County of Dorset. He also became one of the twelve original members of the Order of Merit and a Privy Councillor in the Coronation Honours in 1902.
Later life 
Lister retired from practice after his wife, who had long helped him in research, died in 1892 in Italy, during one of the few holidays they allowed themselves. Studying and writing lost appeal for him and he sank into religious melancholy. Despite suffering a stroke, he still came into the public light from time to time. Edward VII came down with appendicitis two days before his coronation. Like all internal surgery at the time, the appendectomy needed by the King still posed an extremely high risk of death by post-operational infection, and surgeons did not dare operate without consulting Britain's leading surgical authority. Lister obligingly advised them in the latest antiseptic surgical methods (which they followed to the letter), and the King survived, later telling Lister, "I know that if it had not been for you and your work, I wouldn't be sitting here today."
Lister died on 10 February 1912 at his country home in Walmer, Kent at the age of 84. After a funeral service at Westminster Abbey, he was buried at Hampstead Cemetery, Fortune Green, London in a plot to the south-west of central chapel. Both the baronetcy and barony became extinct on his death.
Legacy and honours 
Lister was president of the Royal Society between 1895 and 1900. Following his death, a Memorial Fund led to the founding of the Lister Medal, seen as the most prestigious prize that could be awarded to a surgeon.
A British Institution of Preventive Medicine, previously named after Edward Jenner was renamed in 1899 in honour of Lister.
Two postage stamps were issued in September 1965 to honour Lister for his contributions to antiseptic surgery.
Lister is one of the two surgeons in the United Kingdom who have the honour of having a public monument in London. Lister's stands in Portland Place; the other surgeon is John Hunter. There is a statue of Lister in Kelvingrove Park, Glasgow, celebrating his links with the city.
A building at Glasgow Royal Infirmary which houses cytopathology, microbiology and pathology departments was named in his honour to recognise his work at the hospital.
In 1879, Listerine mouthwash was named after him for his work in antisepsis. Microorganisms named in his honour include the pathogenic bacterial genus Listeria named by J.H.H. Pirie, typified by the food-borne pathogen Listeria monocytogenes, as well as the slime mould genus Listerella, first described by Eduard Adolf Wilhelm Jahn in 1906.
He is depicted in the Academy Award winning 1936 film, The Story of Louis Pasteur, by Halliwell Hobbes. In the film, Lister is one of the beleaguered microbiologist's most noted supporters in the otherwise largely hostile medical community and is the key speaker in the ceremony in his honor.
See also 
- Discoveries of anti-bacterial effects of penicillium moulds before Fleming
- Joseph Sampson Gamgee
- Museum of Health Care
- Ignaz Semmelweis
- Doctors – The History of Medicine through Biography by Sherwin B. Nuland
- John Bankston (2004). Joseph Lister and the Story of Antiseptics (Uncharted, Unexplored, and Unexplained). Bear, Del: Mitchell Lane Publishers. ISBN 1-58415-262-1.
- "Sketch of Sir Joseph Lister". Popular science monthly. Mar 1898. Retrieved 14 May 2013.
- Ann Lamont (March 1992). "Joseph Lister: father of modern surgery". Creation 14 (2): 48–51. "Lister married Syme's daughter Agnes and became a member of the Episcopal church"
- Robinson, Victor. The Story Of Medicine. Kessinger Publishing. p. 420.
- Louis, Fu Kuo-Tai (2011). "Great Names in the History of Orthopaedics XIV: Joseph Lister (1827 e 1912) Part 2". Journal of Orthopaedics, Trauma and Rehabilitation (15): 33.
- Bynum, W. F. Science and the practice of Medicine in the Nineteenth Century, Cambridge:Cambridge, 1994.
- The Lancet, "On a new method of treating compound fracture, abscess, etc.: with observation on the conditions of suppuration".
5 articles running from:
Volume 89, Issue 2272, 16 March 1867, Pages 326-329 (Originally published as Volume 1, Issue 2272)
Volume 90, Issue 2291, 27 July 1867, Pages 95-96 Originally published as Volume 2, Issue 2291
- Lister J (21 September 1867). "On the Antiseptic Principle in the Practice of Surgery". The British Medical Journal 2 (351): 245–260. PMC 2310614. PMID 20744875.. Reprinted in Lister, BJ (2010). "The classic: On the antiseptic principle in the practice of surgery. 1867". Clinical orthopaedics and related research 468 (8): 2012–6. doi:10.1007/s11999-010-1320-x. PMC 2895849. PMID 20361283.
- Lister, Joseph. "Modern History Sourcebook: Joseph Lister (1827-1912): Antiseptic Principle Of The Practice Of Surgery, 1867". Fordham University. Retrieved 2 September 2011.Modernized version of text
- Lister, Joseph. "On the Antiseptic Principle of the Practice of Surgery by Baron Joseph Lister". Project Gutenberg. Retrieved 2 September 2011. E-text, audio at Project Gutenberg.
- "Transactions of the Clinical Society of London Volume 18 1886". Clinical Society. Retrieved 2012-10-23. archive.org
- The London Gazette: . 28 December 1883.
- The London Gazette: . 9 February 1897.
- The Times, Friday, Jan 01, 1897; Issue 35089; p. 8; col A
- Coronation Honours. The Times, Thursday, Jun 27, 1902; Issue 36804; p. 5; col B
- "Mount Lister". Geographic Names Information System, U.S. Geological Survey. Retrieved 2010-02-09.
|Wikimedia Commons has media related to: Joseph Lister, 1st Baron Lister|
|Wikisource has original works written by or about:
- The Lister Institute
- Collection of portraits of Lister at the National Portrait Gallery, London
- Statue of Sir Joseph Lister by Louis Linck at The International Museum of Surgical Science in Chicago
- Commemorative plaque to Lord Lister at the Edinburgh Medical School
|Peerage of the United Kingdom|
|New creation||Baron Lister