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AP-1 complex subunit sigma-2 is a protein that in humans is encoded by the AP1S2gene.[5][6][7]
Function
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants utilizing alternative polyadenylation signals exist for this gene.[7]
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Coleman SH, Hitchin D, Noviello CM, Guatelli JC (February 2006). "HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment". Virology. 345 (1): 148–55. doi:10.1016/j.virol.2005.09.045. PMID16253302.